Aquaporin-4 in glioma invasion and an analysis of molecular mechanisms

被引：56

作者：

Ding, Ting ^{[2
]}

Gu, Feng ^{[2
]}

Fu, Li ^{[2
]}

Ma, Yong-Jie ^{[1
]}

机构：

[1] Tianjin Med Univ, Canc Inst & Hosp, Key Lab Canc Prevent & Therapy Tianjin, Cent Lab Oncol, Tianjin 300060, Peoples R China

[2] Minist Educ, Key Lab Breast Canc Prevent & Therapy, Dept Breast Pathol, Tianjin, Peoples R China

来源：

JOURNAL OF CLINICAL NEUROSCIENCE | 2010年 / 17卷 / 11期

关键词：

Actin cytoskeleton; AQP4; Cell migration; Glioma; Invasion; WATER CHANNEL PROTEIN; HUMAN BRAIN-TUMORS; CELL-MIGRATION; BETA-CATENIN; EXPRESSION; REDISTRIBUTION; LOCALIZATION; TRANSPORT; MOTILITY; CANCER;

D O I：

10.1016/j.jocn.2010.02.014

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

Aquaporin-4 (AQP4) is the most important member of the aquaporin (AQP) family in the central nervous system and has a key role in maintaining water and ion homeostasis. It is clear that AQP4 participates in brain edema after injury and other brain diseases. Various studies report that AQP4 is significantly up-regulated in glioblastoma multiforme compared to low-grade glioma and normal brain tissue, suggesting that it might be involved in tumor malignancy as well as regulation of brain edema. Recent discoveries of AQP4 involvement in cell migration and cytoskeleton organization suggest that AQP4 has a critical role in glioma malignancy. This review focuses on the newly discovered functions and molecular mechanisms of AQP4 in infiltrative gliomas. (c) 2010 Elsevier Ltd. All rights reserved.

引用

页码：1359 / 1361

页数：3

共 33 条

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