Cytotoxic Triterpenoids from Azadirachta indica

被引：17

作者：

Chen, JinXiong ^{[2
]}

Chen, JianChao

Sun, Yun ^{[2
]}

Yan, YuXin ^{[2
]}

Kong, LingMei ^{[2
]}

Li, Yan

Qiu, MingHua ^{[1
]}

机构：

[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China

[2] Chinese Acad Sci, Grad Sch, Beijing, Peoples R China

来源：

PLANTA MEDICA | 2011年 / 77卷 / 16期

关键词：

Meliaceae; Azadirachta indica; tirucallane triterpenoid; tetranortriterpenoid; cytotoxicity; TETRANORTRITERPENOIDS;

D O I：

10.1055/s-0030-1271197

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Two new tirucallane triterpenoids, 24,25-epoxy-3 beta-hydroxy-20-oxo- 7-tirucallene (1) and 22,23; 24,25-diepoxy-3 beta-hydroxy-7-tirucallene (2), and a new tetranortriterpenoid, 4 alpha-hydroperoxy- 6-O-acetylnimbandiol (3), along with eight known compounds, were isolated from the branches and leaves of Azadirachta indica. Their structures were elucidated through spectroscopic and chemical methods. The cytotoxic assay showed that the abundant constituent nimbolide (8) had obvious cytotoxic activities against HL-60, SMMC7721, A549, MCF-7, and SW-480 cell lines, with IC50 values of 0.8 +/- 0.1, 2.2 +/- 0.2, 1.9 +/- 1.3, 4.5 +/- 1.1, and 2.3 +/- 0.1 mu M, respectively.

引用

页码：1844 / 1847

页数：4

共 19 条

[1]

Melanogenesis Inhibitory, Anti-Inflammatory, and Chemopreventive Effects of Limonoids from the Seeds of Azadirachta indicia A. Juss. (Neem) [J].