Mechanism of redox-mediated guanine nucleotide exchange on redox-active rho GTPases

被引：106

作者：

Heo, J

Campbell, SL

机构：

[1] Univ N Carolina, Dept Biochem & Biophys, Chapel Hill, NC 27599 USA

[2] Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 2005年 / 280卷 / 35期

关键词：

D O I：

10.1074/jbc.M504768200

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Rho GTPases regulate multiple cellular processes including actin cytoskeletal rearrangements, transcriptional regulation, and oxidant production. The studies described herein demonstrate that small molecule redox agents, in addition to protein regulatory factors, can regulate the activity of redox- active Rho GTPases. A novel ( GXXXXGK( S/ T) C) motif, conserved in a number of Rho GTPases, appears critical for redox- mediated guanine nucleotide dissociation in vitro. A detailed molecular mechanism for redox regulation of GXXXXGK( S/ T) C motif- containing Rho GTPases is proposed.

引用

收藏

页码：31003 / 31010

页数：8

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