The Noc proteins involved in ribosome synthesis and export contain divergent HEAT repeats

被引：15

作者：

Dlakic, M ^{[1
]}

Tollervey, D

机构：

[1] Montana State Univ, Dept Microbiol, Bozeman, MT 59717 USA

[2] Univ Edinburgh, Wellcome Trust, Ctr Cell Biol, Edinburgh EH9 3JR, Midlothian, Scotland

来源：

RNA | 2004年 / 10卷 / 03期

关键词：

rRNA; ribosome formation; ribonucleoproteins; molecular models; yeast;

D O I：

10.1261/rna.5184704

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Noc1-4p proteins were previously reported to be involved in intranuclear and nucleocytoplasmic transport of pre-ribosomes. Using fold recognition and structural modeling, we show that Noc1-4p are largely comprised of alpha-helical repeats similar to HEAT repeats. Because other HEAT-repeat proteins play key roles in transport processes, this finding provides a plausible mechanistic explanation for the function of the Noc proteins.

引用

页码：351 / 354

页数：4

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