RNAi-directed assembly of heterochromatin in fission yeast

被引：110

作者：

Verdel, A ^{[1
]}

Moazed, D ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

来源：

FEBS LETTERS | 2005年 / 579卷 / 26期

关键词：

heterochromatin; RNAi; RITS; CIr4; histone methylation; epigenetics; transcriptional gene silencing;

D O I：

10.1016/j.febslet.2005.08.083

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Heterochromatin is an epigenetically heritable and conserved feature of eukaryotic chromosomes with important roles in chromosome segregation, genome stability, and gene regulation. The formation of heterochromatin involves an ordered array of chromatin changes, including histone deacetylation, histone H3-lysine 9 methylation, and recruitment of histone binding proteins such as Swi6/HP1. Recent discoveries have uncovered a role for the RNA interference (RNAi) pathway in heterochromatin assembly in the fission yeast Schizosaccharomyces pombe and other eukaryotes. Purification of two RNAi complexes, RITS and RDRC, from fission yeast has provided further insight into the mechanism of RNAi-mediated heterochromatin assembly. These discoveries have given rise to a model in which small interfering RNA molecules act as specificity factors that initiate epigenetic chromatin modifications and double strand RNA synthesis at specific chromosome regions. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：5872 / 5878

页数：7

共 54 条

[1] MicroRNAs: Genomics, biogenesis, mechanism, and function (Reprinted from Cell, vol 116, pg 281-297, 2004) [J].

Bartel, David P. .

CELL, 2007, 131 (04) :11-29

[2] RNA silencing in plants [J].

Baulcombe, D .

NATURE, 2004, 431 (7006) :356-363

[3] Requirement of heterochromatin for cohesion at centromeres [J].

Bernard, P ;

Maure, JF ;

Partridge, JF ;

Genier, S ;

Javerzat, JP ;

Allshire, RC .

SCIENCE, 2001, 294 (5551) :2539-2542

[4] RNA meets chromatin [J].

Bernstein, E ;

Allis, CD .

GENES & DEVELOPMENT, 2005, 19 (14) :1635-1655

[5] Role for a bidentate ribonuclease in the initiation step of RNA interference [J].

Bernstein, E ;

Caudy, AA ;

Hammond, SM ;

Hannon, GJ .

NATURE, 2001, 409 (6818) :363-366

[6]

CAM H, 2005, NAT GENET

[7] miRNAs, cancer, and stem cell division [J].

Croce, CM ;

Calin, GA .

CELL, 2005, 122 (01) :6-7

[8] Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans [J].

Fire, A ;

Xu, SQ ;

Montgomery, MK ;

Kostas, SA ;

Driver, SE ;

Mello, CC .

NATURE, 1998, 391 (6669) :806-811

[9] Heterochromatin and epigenetic control of gene expression [J].

Grewal, SIS ;

Moazed, D .

SCIENCE, 2003, 301 (5634) :798-802

[10] The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage [J].

Groisman, R ;

Polanowska, J ;

Kuraoka, I ;

Sawada, J ;

Saijo, M ;

Drapkin, R ;

Kisselev, AF ;

Tanaka, K ;

Nakatani, Y .

CELL, 2003, 113 (03) :357-367

← 1 2 3 4 5 6 →