Preparation of aminated taxol side chain precursors. A simple approach to 2,3-diamino acids using the beta-lactam synthon method.

被引：23

作者：

Moyna, G ^{[1
]}

Williams, HJ ^{[1
]}

Scott, AI ^{[1
]}

机构：

[1] TEXAS A&M UNIV,DEPT CHEM,CTR BIOL NMR,COLLEGE STN,TX 77843

来源：

SYNTHETIC COMMUNICATIONS | 1997年 / 27卷 / 09期

关键词：

D O I：

10.1080/00397919708006094

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Coupling-ready aminated side chain analog precursors of the anticancer drug taxol were prepared through the beta-lactam synthon method. The procedure described represents an easy connection between beta-lactams and 2,3-diamino acids, is highly stereospecific, and causes no racemization due to vicinal group participation.

引用

页码：1561 / 1567

页数：7

共 19 条

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