Internal resin capture - A self purification method for the synthesis of C-terminally modified peptides

被引：21

作者：

Davies, M ^{[1
]}

Bradley, M ^{[1
]}

机构：

[1] Univ Southampton, Dept Chem, Southampton SO17 1BJ, Hants, England

来源：

TETRAHEDRON | 1999年 / 55卷 / 15期

基金：

英国生物技术与生命科学研究理事会; 英国工程与自然科学研究理事会;

关键词：

combinatorial; peptides; solid-phase; linkers;

D O I：

10.1016/S0040-4020(99)00146-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A synthetic strategy which allows for the general modification of peptides at the C-terminus has long been the goal of the synthetic chemist. We report here the full synthetic details of our inversion and modification methodology demonstrating the method with the synthesis of peptide amides, alcohols, nitriles and a range of other modified peptides. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：4733 / 4746

页数：14

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