The isoprostanes: Their quantification as an index of oxidant stress status in vivo

被引：164

作者：

Morrow, JD

机构：

[1] Vanderbilt Univ, Sch Med, Dept Med, Nashville, TN 37232 USA

[2] Vanderbilt Univ, Sch Med, Dept Pharmacol, Nashville, TN 37232 USA

来源：

DRUG METABOLISM REVIEWS | 2000年 / 32卷 / 3-4期

关键词：

D O I：

10.1081/DMR-100102340

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The F-2 isoprostanes are a unique series of prostaglandinlike compounds formed in vivo from the fine-radical-catalyzed peroxidation of arachidonic acid independent of the cyclooxygenase enzyme. The purpose of this review is to briefly summarize the status of our current knowledge regarding the isoprostanes. Novel aspects related to the biochemistry of isoprostane formation and methods by which these compounds are analyzed are discussed. The utility of measuring F-2 isoprostanes as markers of lipid peroxidation in animal models of oxidant stress are then outlined. Finally, examples are provided in which quantification of isoprostanes have illuminated the role of oxidative injury in several human diseases.

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页码：377 / 385

页数：9

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