Pathobiology of Colorectal Cancer Hepatic Metastases With an Emphasis on Prognostic Factors

被引：42

作者：

LeGolvan, Mark P. ^{[1
]}

Resnick, Murray ^{[1
]}

机构：

[1] Brown Univ, Warren Alpert Sch Med, Rhode Isl Hosp, Dept Pathol, Providence, RI 02903 USA

来源：

JOURNAL OF SURGICAL ONCOLOGY | 2010年 / 102卷 / 08期

关键词：

angiogenesis; cadherins; epithelial-mesenchymal transformation EMT; integrins; miRNA; ENDOTHELIAL GROWTH-FACTOR; PLASMINOGEN-ACTIVATOR INHIBITOR-1; MATRIX METALLOPROTEINASES MMPS; CARCINOEMBRYONIC ANTIGEN CEA; CHEMOKINE RECEPTORS CXCR4; MEMBRANE-BOUND INHIBITOR; MESSENGER-RNA EXPRESSION; CHROMOSOME 18Q DELETION; CELL-ADHESION MOLECULES; TUMOR-SUPPRESSOR GENE;

D O I：

10.1002/jso.21817

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Colorectal cancer is the second leading cause of cancer related death in the United States. The majority of these deaths are due to metastasis, with the liver easily accounting as the most common site of deposit. While there are multiple steps in the CRC hepatic metastatic cascade, this review attempts to summarize the different processes involved, focusing on the most recent discoveries, as well as the associated effects in relation to prognosis. J. Surg. Oncol. 2010; 102: 898-908. (C) 2010 Wiley-Liss, Inc.

引用

页码：898 / 908

页数：11

共 135 条

[1] Carcinoembryonic antigen-stimulated THP-1 macrophages activate endothelial cells and increase cell-cell adhesion of colorectal cancer cells [J].

Aarons, Cary B. ;

Bajenova, Olga ;

Andrews, Charles ;

Heydrick, Stanley ;

Bushell, Kristen N. ;

Reed, Karen L. ;

Thomas, Peter ;

Becker, James M. ;

Stucchi, Arthur F. .

CLINICAL & EXPERIMENTAL METASTASIS, 2007, 24 (03) :201-209

[2]

Ahmad SA, 2001, CANCER, V92, P1138, DOI 10.1002/1097-0142(20010901)92:5<1138::AID-CNCR1431>3.0.CO

[3]

2-L

[4]

[Anonymous], 2009, SEER Cancer Statistics Review, 1975-2006

[5] MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer [J].

Asangani, I. A. ;

Rasheed, S. A. K. ;

Nikolova, D. A. ;

Leupold, J. H. ;

Colburn, N. H. ;

Post, S. ;

Allgayer, H. .

ONCOGENE, 2008, 27 (15) :2128-2136

[6] Prognostic values of matrix metalloproteinase family expression in human colorectal carcinoma [J].

Asano, Toshimichi ;

Tada, Mitsuhiro ;

Cheng, Shaoqiang ;

Takemoto, Norihiro ;

Kuramae, Taro ;

Abe, Motoki ;

Takahashi, Osamu ;

Miyamoto, Masaki ;

Hamada, Jun-Ichi ;

Moriuchi, Tetsuya ;

Kondo, Satoshi .

JOURNAL OF SURGICAL RESEARCH, 2008, 146 (01) :32-42

[7] Evolving role of uPA/uPAR system in human cancers [J].

Ass, Kathleen ;

Ahmad, Aamir ;

Azmi, Asfar S. ;

Sarkar, Sarah H. ;

Sarkar, Fazlul H. .

CANCER TREATMENT REVIEWS, 2008, 34 (02) :122-136

[8] Integrins [J].

Barczyk, Malgorzata ;

Carracedo, Sergio ;

Gullberg, Donald .

CELL AND TISSUE RESEARCH, 2010, 339 (01) :269-280

[9] Molecular Mechanisms of Resistance to Cetuximab and Panitumumab in Colorectal Cancer [J].

Bardelli, Alberto ;

Siena, Salvatore .

JOURNAL OF CLINICAL ONCOLOGY, 2010, 28 (07) :1254-1261

[10] Transcriptional activation of integrin β6 during the epithelial-mesenchymal transition defines a novel prognostic indicator of aggressive colon carcinoma [J].

Bates, RC ;

Bellovin, DI ;

Brown, C ;

Maynard, E ;

Wu, BY ;

Kawakatsu, H ;

Sheppard, D ;

Oettgen, P ;

Mercurio, AM .

JOURNAL OF CLINICAL INVESTIGATION, 2005, 115 (02) :339-347

← 1 2 3 4 5 6 7 8 9 10 →