Pathobiology of Colorectal Cancer Hepatic Metastases With an Emphasis on Prognostic Factors

被引：42

作者：

LeGolvan, Mark P. ^{[1
]}

Resnick, Murray ^{[1
]}

机构：

[1] Brown Univ, Warren Alpert Sch Med, Rhode Isl Hosp, Dept Pathol, Providence, RI 02903 USA

来源：

JOURNAL OF SURGICAL ONCOLOGY | 2010年 / 102卷 / 08期

关键词：

angiogenesis; cadherins; epithelial-mesenchymal transformation EMT; integrins; miRNA; ENDOTHELIAL GROWTH-FACTOR; PLASMINOGEN-ACTIVATOR INHIBITOR-1; MATRIX METALLOPROTEINASES MMPS; CARCINOEMBRYONIC ANTIGEN CEA; CHEMOKINE RECEPTORS CXCR4; MEMBRANE-BOUND INHIBITOR; MESSENGER-RNA EXPRESSION; CHROMOSOME 18Q DELETION; CELL-ADHESION MOLECULES; TUMOR-SUPPRESSOR GENE;

D O I：

10.1002/jso.21817

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Colorectal cancer is the second leading cause of cancer related death in the United States. The majority of these deaths are due to metastasis, with the liver easily accounting as the most common site of deposit. While there are multiple steps in the CRC hepatic metastatic cascade, this review attempts to summarize the different processes involved, focusing on the most recent discoveries, as well as the associated effects in relation to prognosis. J. Surg. Oncol. 2010; 102: 898-908. (C) 2010 Wiley-Liss, Inc.

引用

页码：898 / 908

页数：11

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