Highly functionalized cyclopentanes from meso bicyclic hydrazines. A rapid access to mannosidase inhibitors

被引：21

作者：

Bournaud, C

Robic, D

Bonin, M

Micouin, L

机构：

[1] Univ Paris 05, Fac Sci Pharmaceut & Biol, F-75270 Paris, France

[2] CNRS, UMR 8638, Chim Therapeut Lab, F-75270 Paris, France

[3] CNRS, UMR 8015, Cristallog Lab, F-75270 Paris, France

[4] CNRS, UMR 8015, RMN Biol, F-75270 Paris, France

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2005年 / 70卷 / 08期

关键词：

D O I：

10.1021/jo047778d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple diastereoselective access to amino- and hydrazinocyclopentitols is described. The key step involves a cationic rearrangement of a meso bicyclic hydrazine, followed by two successive stereoselective hydroxylations. Both racemic compounds are micromolar alpha-mannosidase (Jack bean) inhibitors.

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收藏

页码：3316 / 3317

页数：2

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