Biological properties of single chemical-DNA adducts: A twenty year perspective

被引：77

作者：

Delaney, James C.

Essigmann, John M. ^{[1
]}

机构：

[1] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

CHEMICAL RESEARCH IN TOXICOLOGY | 2008年 / 21卷 / 01期

关键词：

D O I：

10.1021/tx700292a

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The genome and its nucleotide precursor pool are under sustained attack by radiation, reactive oxygen and nitrogen species, chemical carcinogens, hydrolytic reactions, and certain drugs. As a result, a large and heterogeneous population of damaged nucleotides forms in all cells. Some of the lesions are repaired, but for those that remain, there can be serious biological consequences. For example, lesions that form in DNA can lead to altered gene expression, mutation, and death. This perspective examines systems developed over the past 20 years to study the biological properties of single DNA lesions.

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页码：232 / 252

页数：21

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