Association between the SDF1-3′A allele and high levels of CD34+ progenitor cells mobilized into peripheral blood in humans

被引：59

作者：

Benboubker, L

Watier, H

Carion, A

Georget, MT

Desbois, I

Colombat, P

Bardos, P

Binet, C

Domenech, J

机构：

[1] Univ Tours, UPRES EA Haematopoiet Cells Haemostasis & Transpl, F-37041 Tours, France

[2] Univ Hosp Tours, Reg Blood Bank, Tours, France

[3] Univ Hosp Tours, Immunol Lab, Tours, France

[4] Univ Hosp Tours, Dept Med Oncol & Blood Dis, Tours, France

[5] Univ Hosp Tours, Haematol Lab, Tours, France

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2001年 / 113卷 / 01期

关键词：

SDF-3 ' A polymorphism; peripheral blood progenitor cells; CD34(+) cells; mobilization;

D O I：

10.1046/j.1365-2141.2001.02717.x

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Some patients unexpectedly fail to mobilize sufficient numbers of haematopoietic progenitor cells (HPCs) into the peripheral blood for autologous transplantation. Considering the important role of the chemokine stromal cell-derived factor 1 (SDF-1) in HPC homing, we investigated a possible relationship between SDF1 gene polymorphism and HPC mobilization capacity in 63 patients with malignancy. Some 67% of the good mobilizers (greater than or equal to 50 CD34(+) cells/mul) and only 36% of the intermediate/poor mobilizers were SDF1-3 'A allele carriers (P = 0.032). In multivariate analysis, the presence of the SDF1-3 'A allele was the only factor predictive of good CD34(+) cell mobilization (P = 0.025), This is the first report showing the involvement of genetic factors for HPC mobilization in humans and suggests a significant role for SDF-1 in this process.

引用

页码：247 / 250

页数：4

共 12 条

[1]

The chemokine SDF-1 is a chemoattractant for human CD34(+) hematopoietic progenitor cells and provides a new mechanism to explain the mobilization of CD34(+) progenitors to peripheral blood [J].