Approaches to oximidines, lobatamides and related natural products:: the coupling reactions of 3-iodoacrolein O-methyl oximes

被引：16

作者：

Raw, SA ^{[1
]}

Taylor, RJK ^{[1
]}

机构：

[1] Univ York, Dept Chem, York YO10 5DD, N Yorkshire, England

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 52期

关键词：

D O I：

10.1016/S0040-4039(00)01862-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Both 2E- and 2Z-3-iodoacrolein O-methyl oximes are prepared in two steps from ethyl propiolate. Lithium-iodine exchange is effected and the resulting organolithium reagents added to several electrophiles, including styryl isocyanate which gives a conjugated O-methyl oxime enamide of the type found in the side chains of the oximidine, lobatamide and CJ-12950 natural products. The Pd(0) catalysed cross-coupling of these iodoalkenes is also explored. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：10357 / 10361

页数：5

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