Salicylihalamides A and B, novel cytotoxic macrolides from the marine sponge Haliclona sp.

被引：236

作者：

Erickson, KL ^{[1
]}

Beutler, JA ^{[1
]}

Cardellina, JH ^{[1
]}

Boyd, MR ^{[1
]}

机构：

[1] NCI, FREDERICK CANC RES & DEV CTR, LAB DRUG DISCOVERY RES & DEV, DEV THERAPEUT PROGRAM, FREDERICK, MD 21702 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1997年 / 62卷 / 23期

关键词：

D O I：

10.1021/jo971556g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two novel, highly potent, cytotoxic macrolides, salicylihalamides A (1) and B (2), were isolated from the sponge Haliclona sp. This new macrolide class incorporates salicylic acid, a 12-membered lactone ring, and an enamide side chain. COMPARE pattern-recognition analyses of the NCI 60-cell mean graph screening profiles of 1 did not reveal any significant correlations to the profiles of known antitumor compounds in the NCI's ''standard agent database'', thus supporting the conclusion that the salicylihalamides represent a potentially important new class for antitumor lead optimization and in vivo investigations.

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收藏

页码：8188 / 8192

页数：5

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