New gatekeepers of reproduction: GPR54 and its cognate ligand, KiSS-1

被引:51
作者
Seminara, SB
Kaiser, UB
机构
[1] Brigham & Womens Hosp, Dept Med, Div Endocrinol Diabet & Hypertens, Boston, MA 02115 USA
[2] Harvard Univ, Sch Med, Boston, MA 02115 USA
[3] Massachusetts Gen Hosp, Reprod Endocrine Unit, Boston, MA 02115 USA
关键词
D O I
10.1210/en.2005-0070
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:1686 / 1688
页数:3
相关论文
共 23 条
[1]   Differential regulation of gonadotropin subunit gene promoter activity by pulsatile gonadotropin-releasing hormone (GnRH) in perifused LβT2 cells:: Role of GnRH receptor concentration [J].
Bédécarrats, GY ;
Kaiser, UB .
ENDOCRINOLOGY, 2003, 144 (05) :1802-1811
[2]   Two common naturally occurring mutations in the human gonadotropin-releasing hormone (GnRH) receptor have differential effects on gonadotropin gene expression and on GnRH-mediated signal transduction [J].
Bedecarrats, GY ;
Linher, KD ;
Kaiser, UB .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2003, 88 (02) :834-843
[3]   THE FREQUENCY OF GONADOTROPIN-RELEASING-HORMONE STIMULATION DIFFERENTIALLY REGULATES GONADOTROPIN SUBUNIT MESSENGER RIBONUCLEIC-ACID EXPRESSION [J].
DALKIN, AC ;
HAISENLEDER, DJ ;
ORTOLANO, GA ;
ELLIS, TR ;
MARSHALL, JC .
ENDOCRINOLOGY, 1989, 125 (02) :917-924
[4]   Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54 [J].
de Roux, N ;
Genin, E ;
Carel, JC ;
Matsuda, F ;
Chaussain, JL ;
Milgrom, E .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (19) :10972-10976
[5]   The KiSS-1 receptor GPR54 is essential for the development of the murine reproductive system [J].
Funes, S ;
Hedrick, JA ;
Vassileva, G ;
Markowitz, L ;
Abbondanzo, S ;
Golovko, A ;
Yang, SJ ;
Monsma, FJ ;
Gustafson, EL .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2003, 312 (04) :1357-1363
[6]   A role for kisspeptins in the regulation of gonadotropin secretion in the mouse [J].
Gottsch, ML ;
Cunningham, MJ ;
Smith, JT ;
Popa, SM ;
Acohido, BV ;
Crowley, WF ;
Seminara, S ;
Clifton, DK ;
Steiner, RA .
ENDOCRINOLOGY, 2004, 145 (09) :4073-4077
[7]   Dramatic elevation of plasma metastin concentrations in human pregnancy: Metastin as a novel placenta-derived hormone in humans [J].
Horikoshi, Y ;
Matsumoto, H ;
Takatsu, Y ;
Ohtaki, T ;
Kitada, C ;
Usuki, S ;
Fujino, M .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2003, 88 (02) :914-919
[8]   Kisspeptin activation of gonadotropin releasing hormone neurons and regulation of KiSS-1 mRNA in the male rat [J].
Irwig, MS ;
Fraleyb, GS ;
Smith, JT ;
Acohido, BV ;
Popa, SM ;
Cunningham, MJ ;
Gottsch, ML ;
Clifton, DK ;
Steiner, RA .
NEUROENDOCRINOLOGY, 2004, 80 (04) :264-272
[9]   The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54 [J].
Kotani, M ;
Detheux, M ;
Vandenbbogaerde, A ;
Communi, D ;
Vanderwinden, JM ;
Le Poul, E ;
Brézillon, S ;
Tyldesley, R ;
Suarez-Huerta, N ;
Vandeput, F ;
Blanpain, C ;
Schiffmann, SN ;
Vassart, G ;
Parmentier, M .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (37) :34631-34636
[10]  
Lee JH, 1997, CANCER RES, V57, P2384