Enhancement of hematopoietic stem cell repopulating capacity and self-renewal in the absence of the transcription factor C/EBPα.

被引：415

作者：

Zhang, P

Iwasaki-Arai, J

Iwasaki, H

Fenyus, ML

Dayaram, T

Owens, BM

Shigematsu, H

Levantini, E

Huettner, CS

Lekstrom-Himes, JA

Akashi, K

Tenen, DG ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dana Farber Canc Inst, Inst Med, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Canc Immunol & AIDS, Boston, MA 02115 USA

[3] NIAID, Host Def Lab, Bethesda, MD 20892 USA

来源：

IMMUNITY | 2004年 / 21卷 / 06期

关键词：

D O I：

10.1016/j.immuni.2004.11.006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The transcription factor C/EBPalpha is required for granulopoiesis and frequently disrupted in human acute myeloid leukemia (AML). Here, we show disruption of C/EBPalpha blocks the transition from the common myeloid to the granulocyte/monocyte progenitor but is not required beyond this stage for terminal granulocyte maturation. C/EBPalpha-deficient hematopoietic stem cells (HSCs) have increased expression of Bmi-1 and enhanced competitive repopulating activity. Bone marrow in adult C/EBPa-deficient mice was filled with myeloblasts, similar to human AML, supporting the notion that disruption of C/EBPalpha cooperates with other events in the development of leukemia. Therefore, C/EBPalpha is not only essential for granulocyte development but, in addition, is a regulator of hematopoietic stem cell activity.

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页码：853 / 863

页数：11

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