Glutathione peroxidase-like activities of oxygen-containing diselenides

被引：102

作者：

Wirth, T ^{[1
]}

机构：

[1] Univ Basel, Inst Organ Chem, CH-4056 Basel, Switzerland

来源：

MOLECULES | 1998年 / 3卷 / 07期

关键词：

antioxidants; diselenides; glutathione oxidase; glutathione peroxidase; oxidative stress;

D O I：

10.3390/30700164

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Various diselenides 1-8 have been examined with respect to their glutathione peroxidase-like activities (GPx-activities) as an index of their antioxidant properties. The glutathione oxidase activities of these compounds have also been reviewed reflecting the pro-oxidant properties (GOx-activities) and could be used as an index of cell toxicity.:Based on a qualitative structure-activity relationship some trends are suggested.

引用

收藏

页码：164 / 166

页数：3

相关论文

共 24 条

[11] BENZOSELENAZOLINONE DERIVATIVES DESIGNED TO BE GLUTATHIONE-PEROXIDASE MIMETICS FEATURE INHIBITION OF CYCLOOXYGENASE/5-LIPOXYGENASE PATHWAYS AND ANTIINFLAMMATORY ACTIVITY [J].

GALET, V ;

BERNIER, JL ;

HENICHART, JP ;

LESIEUR, D ;

ABADIE, C ;

ROCHETTE, L ;

LINDENBAUM, A ;

CHALAS, J ;

DELAFAVERIE, JFR ;

PFEIFFER, B ;

RENARD, P .

JOURNAL OF MEDICINAL CHEMISTRY, 1994, 37 (18) :2903-2911

[12] A MODEL STUDY ON THE EFFECT OF AN AMINO GROUP ON THE ANTIOXIDANT ACTIVITY OF GLUTATHIONE-PEROXIDASE [J].

IWAOKA, M ;

TOMODA, S .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1994, 116 (06) :2557-2561

[13] STRUCTURE-ANALYSIS AND MOLECULAR-MODEL OF THE SELENOENZYME GLUTATHIONE-PEROXIDASE AT 2.8 A RESOLUTION [J].

LADENSTEIN, R ;

EPP, O ;

BARTELS, K ;

JONES, A ;

HUBER, R ;

WENDEL, A .

JOURNAL OF MOLECULAR BIOLOGY, 1979, 134 (02) :199-218

[14] Benzisoselenazol-3(2H)-ones and bis(2-carbamoyl)phenyl diselenides as new catalysts for hydrogen peroxide oxidation of organic compounds [J].

Mlochowski, J ;

Giurg, M ;

Kubicz, E ;

Said, SB .

SYNTHETIC COMMUNICATIONS, 1996, 26 (02) :291-300

[15]

PAGLIA DE, 1967, J LAB CLIN MED, V70, P158

[16] ORGANOSELENIUM CHEMISTRY - REDOX CHEMISTRY OF SELENOCYSTEINE MODEL SYSTEMS [J].

REICH, HJ ;

JASPERSE, CP .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1987, 109 (18) :5549-5551

[17] SELENIUM - BIOCHEMICAL ROLE AS A COMPONENT OF GLUTATHIONE PEROXIDASE [J].

ROTRUCK, JT ;

POPE, AL ;

GANTHER, HE ;

SWANSON, AB ;

HAFEMAN, DG ;

HOEKSTRA, WG .

SCIENCE, 1973, 179 (4073) :588-590

[18] EBSELEN, A SELENOORGANIC COMPOUND AS GLUTATHIONE-PEROXIDASE MIMIC [J].

SIES, H .

FREE RADICAL BIOLOGY AND MEDICINE, 1993, 14 (03) :313-323

[19]

STADTMAN TC, 1991, J BIOL CHEM, V266, P16257

[20] A NEW ROUTE TO SELENO AND TELLURO ESTERS BY CO2(CO)8-MEDIATED AND CO2(CO)8-CATALYZED CARBONYLATION OF DIARYL DISELENIDES AND DITELLURIDES WITH CARBON-MONOXIDE [J].

UEMURA, S ;

TAKAHASHI, H ;

OHE, K ;

SUGITA, N .

JOURNAL OF ORGANOMETALLIC CHEMISTRY, 1989, 361 (01) :63-72