Gliding motility and cell invasion by Apicomplexa:: insights from the Plasmodium sporozoite

被引:92
作者
Ménard, R [1 ]
机构
[1] Inst Pasteur, Lab Biol & Genet Paludisme, F-75724 Paris 15, France
关键词
D O I
10.1046/j.1462-5822.2001.00097.x
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Apicomplexa constitute one of the largest phyla of protozoa. Most Apicomplexa, including those pathogenic to humans, are obligate intracellular parasites. Their extracellular forms, which are highly polarized and elongated cells, share two unique abilities: they glide on solid substrates without changing their shape and reach an intracellular compartment without active participation from the host cell. There is now ample ultrastructural evidence that these processes result from the backward movement of extracellular interactions along the anteroposterior axis of the parasite. Recent work in several Apicomplexa, including genetic studies in the Plasmodium sporozoite, has provided molecular support for this 'capping' model. It appears that the same machinery drives both gliding motility and host cell invasion. The cytoplasmic motor, a transmembrane bridge and surface ligands essential for cell invasion are conserved among the main apicomplexan pathogens.
引用
收藏
页码:63 / 73
页数:11
相关论文
共 97 条
[1]   ERYTHROCYTE ENTRY BY MALARIAL PARASITES - MOVING JUNCTION BETWEEN ERYTHROCYTE AND PARASITE [J].
AIKAWA, M ;
MILLER, LH ;
JOHNSON, J ;
RABBEGE, J .
JOURNAL OF CELL BIOLOGY, 1978, 77 (01) :72-82
[2]   Cloning and characterization of actin depolymerizing factor from Toxoplasma gondii [J].
Allen, ML ;
Dobrowolski, JM ;
Muller, H ;
Sibley, LD ;
Mansour, TE .
MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1997, 88 (1-2) :43-52
[3]   IMMUNOFLUORESCENT MICROSCOPIC VISUALIZATION OF TRAILS LEFT BY GLIDING CRYPTOSPORIDIUM-PARVUM SPOROZOITES [J].
ARROWOOD, MJ ;
STERLING, CR ;
HEALEY, MC .
JOURNAL OF PARASITOLOGY, 1991, 77 (02) :315-317
[4]   Functions of cell surface heparan sulfate proteoglycans [J].
Bernfield, M ;
Götte, M ;
Park, PW ;
Reizes, O ;
Fitzgerald, ML ;
Lincecum, J ;
Zako, M .
ANNUAL REVIEW OF BIOCHEMISTRY, 1999, 68 :729-777
[5]   Secretion of micronemal proteins is associated with toxoplasma invasion of host cells [J].
Carruthers, VB ;
Giddings, OK ;
Sibley, LD .
CELLULAR MICROBIOLOGY, 1999, 1 (03) :225-235
[6]   Mobilization of intracellular calcium stimulates microneme discharge in Toxoplasma gondii [J].
Carruthers, VB ;
Sibley, LD .
MOLECULAR MICROBIOLOGY, 1999, 31 (02) :421-428
[7]  
Carruthers VB, 1997, EUR J CELL BIOL, V73, P114
[8]   THE BASOLATERAL DOMAIN OF THE HEPATOCYTE PLASMA-MEMBRANE BEARS RECEPTORS FOR THE CIRCUMSPOROZOITE PROTEIN OF PLASMODIUM-FALCIPARUM SPOROZOITES [J].
CERAMI, C ;
FREVERT, U ;
SINNIS, P ;
TAKACS, B ;
CLAVIJO, P ;
SANTOS, MJ ;
NUSSENZWEIG, V .
CELL, 1992, 70 (06) :1021-1033
[9]   ULTRASTRUCTURAL OBSERVATIONS OF HOST-CELL INVASION BY SPOROZOITES OF EIMERIA-PAPILLATA INVIVO [J].
CHOBOTAR, B ;
DANFORTH, HD ;
ENTZEROTH, R .
PARASITOLOGY RESEARCH, 1993, 79 (01) :15-23
[10]   MOVING AND STATIONARY ACTIN-FILAMENTS ARE INVOLVED IN SPREADING OF POSTMITOTIC PTK2 CELLS [J].
CRAMER, L ;
MITCHISON, TJ .
JOURNAL OF CELL BIOLOGY, 1993, 122 (04) :833-843