One-pot organocatalytic domino Michael/α-alkylation reactions:: highly enantioselective synthesis of functionalized cyclopentanones and cyclopentanols

被引：64

作者：

Rios, Ramon ^{[1
]}

Vesely, Jan ^{[1
]}

Sunden, Henrik ^{[1
]}

Ibrahem, Ismail ^{[1
]}

Zhao, Gui-Ling ^{[1
]}

Cordova, Armando ^{[1
]}

机构：

[1] Stockholm Univ, Arrhenius Lab, Dept Organ Chem, SE-10691 Stockholm, Sweden

来源：

TETRAHEDRON LETTERS | 2007年 / 48卷 / 33期

关键词：

D O I：

10.1016/j.tetlet.2007.06.070

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple, highly enantioselective catalytic route to cyclopentanones is presented. The chiral airline catalyzed domino Michael/of.-alkvlation reaction gives access to functionalized cyclopentanones in good to high yields with 93 -> 99% ee. The products were also reduced with high diastereoselectivity to the corresponding cyclopentanols. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：5835 / 5839

页数：5

共 55 条

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