Combining pot, atom and step economy (PASE) in organic synthesis. Synthesis of tetrahydropyran-4-ones

被引：281

作者：

Clarke, Paul A. ^{[1
]}

Santos, Soraia

Martin, William H. C.

机构：

[1] Univ York, Dept Chem, York YO10 5DD, N Yorkshire, England

[2] Univ Nottingham, Sch Chem, Nottingham NG7 2RD, England

来源：

GREEN CHEMISTRY | 2007年 / 9卷 / 05期

基金：

英国工程与自然科学研究理事会;

关键词：

D O I：

10.1039/b700923b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The combination of pot, atom and step economy (PASE) in the synthesis of organic molecules of medium complexity can lead to a significant 'greening' of a synthetic route. This is demonstrated by the synthesis of highly substituted tetrahydropyran-4-ones and is quantified by a series of recognised metrics, which demonstrate the efficiency of combining PASE over conventional synthetic strategies.

引用

页码：438 / 440

页数：3

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