Protein kinase D: a family affair

被引：190

作者：

Rykx, A

De Kimpe, L

Mikhalap, S

Vantus, T

Seufferlein, T

Vandenheede, JR

Van Lint, J

机构：

[1] Katholieke Univ Leuven, Fac Med, Div Biochem, B-3000 Louvain, Belgium

[2] Semmelweis Univ, Dept Med Chem, Peptide Biochem Res Grp, Budapest, Hungary

[3] Univ Ulm, Fac Med, Div Internal Med, D-09081 Ulm, Germany

来源：

FEBS LETTERS | 2003年 / 546卷 / 01期

关键词：

protein kinase D; protein kinase Cu; cell proliferation; apoptosis; signal transduction; Golgi apparatus; stress signaling; tumor cell invasion;

D O I：

10.1016/S0014-5793(03)00487-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The protein kinase D family of enzymes consists of three isoforms: PKD1/PKCmu, PKD2 and PKD3/PKCnu. They all share a similar architecture with regulatory sub-domains that play specific roles in the activation, translocation and function of the enzymes. The PKD enzymes have recently been implicated in very diverse cellular functions, including Golgi organization and plasma membrane directed transport, metastasis, immune responses, apoptosis and cell proliferation. (C) 2003 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies.

引用

页码：81 / 86

页数：6

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