Functional dendritic polymer architectures as stimuli-responsive nanocarriers

被引：124

作者：

Calderon, Marcelo ^{[1
]}

Quadir, Mohiuddin A. ^{[1
]}

Strumia, Miriam ^{[2
]}

Haag, Rainer ^{[1
]}

机构：

[1] Free Univ Berlin, Dept Chem & Biochem, D-14195 Berlin, Germany

[2] Univ Nacl Cordoba, Dept Quim Organ, RA-5000 Cordoba, Argentina

来源：

BIOCHIMIE | 2010年 / 92卷 / 09期

关键词：

Stimuli responsive; Dendritic architectures; Nanocarriers; Drug encapsulation; Polymer therapeutics; SELF-IMMOLATIVE DENDRIMERS; DRUG-DELIVERY APPLICATIONS; IN-VIVO; HYPERBRANCHED POLYGLYCEROLS; POLY(ETHYLENE GLYCOL); CONTROLLED-RELEASE; POLYAMIDOAMINE DENDRIMERS; ENZYMATIC ACTIVATION; PAMAM DENDRIMERS; EXTRACELLULAR PH;

D O I：

10.1016/j.biochi.2010.02.017

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Stimuli-responsive polymer architectures are molecular systems which evolve with an external signal. The observed changes are mainly decomposition, isomerization, polymerization, activation, supramolecular aggregation, and structural modifications of these molecules. The external stimuli, which can be combined in order to provoke these molecular changes, are numerous. In this review, we have chosen to present an overview on different mechanisms to impart responsiveness to dendritic polymers, with the particular aim of delivery and release of bioactive molecules. (C) 2010 Elsevier Masson SAS. All rights reserved.

引用

页码：1242 / 1251

页数：10

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