Targeting heat shock protein 72 enhances Hsp90 inhibitor-induced apoptosis in myeloma

被引:61
作者
Davenport, E. L. [1 ]
Zeisig, A. [1 ]
Aronson, L. I. [1 ]
Moore, H. E. [1 ]
Hockley, S. [1 ]
Gonzalez, D. [1 ]
Smith, E. M. [1 ]
Powers, M. V. [2 ]
Sharp, S. Y. [2 ]
Workman, P. [2 ]
Morgan, G. J. [1 ]
Davies, F. E. [1 ]
机构
[1] Inst Canc Res, Sect Haematooncol, Sutton, Surrey, England
[2] Inst Canc Res, Canc Res UK Ctr Canc Therapeut, Sutton, Surrey, England
关键词
MOLECULAR CHAPERONE; HSP70; HEAT-SHOCK-PROTEIN-70;
D O I
10.1038/leu.2010.168
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
引用
收藏
页码:1804 / 1807
页数:5
相关论文
共 9 条
[1]   Untangling the unfolded protein response [J].
Davenport, Emma L. ;
Morgan, Gareth J. ;
Davies, Faith E. .
CELL CYCLE, 2008, 7 (07) :865-869
[2]   Heat shock protein inhibition is associated with activation of the unfolded protein response pathway in myeloma plasma cells [J].
Davenport, Emma L. ;
Moore, Hannah E. ;
Dunlop, Alan S. ;
Sharp, Swee Y. ;
Workman, Paul ;
Morgan, Gareth J. ;
Davies, Faith E. .
BLOOD, 2007, 110 (07) :2641-2649
[3]   Heat Shock Protein 70 (Hsp70) as an Emerging Drug Target [J].
Evans, Christopher G. ;
Chang, Lyra ;
Gestwicki, Jason E. .
JOURNAL OF MEDICINAL CHEMISTRY, 2010, 53 (12) :4585-4602
[4]   Downstream caspases are novel targets for the antiapoptotic activity of the molecular chaperone Hsp70 [J].
Komarova, EY ;
Afanasyeva, EA ;
Bulatova, MM ;
Cheetham, ME ;
Margulis, BA ;
Guzhova, IV .
CELL STRESS & CHAPERONES, 2004, 9 (03) :265-275
[5]   A Small Molecule Inhibitor of Inducible Heat Shock Protein 70 [J].
Leu, J. I-Ju ;
Pimkina, Julia ;
Frank, Amanda ;
Murphy, Maureen E. ;
George, Donna L. .
MOLECULAR CELL, 2009, 36 (01) :15-27
[6]   Antimyeloma activity of heat shock protein-90 inhibition [J].
Mitsiades, CS ;
Mitsiades, NS ;
McMullan, CJ ;
Poulaki, V ;
Kung, AL ;
Davies, FE ;
Morgan, G ;
Akiyama, M ;
Shringarpure, R ;
Munshi, NC ;
Richardson, PG ;
Hideshima, T ;
Chauhan, D ;
Gu, XS ;
Bailey, C ;
Joseph, M ;
Libermann, TA ;
Rosen, NS ;
Anderson, KC .
BLOOD, 2006, 107 (03) :1092-1100
[7]   Dual targeting of HSC70 and HSP72 inhibits HSP90 function and induces tumor-specific apoptosis [J].
Powers, Marissa V. ;
Clarke, Paul A. ;
Workman, Paul .
CANCER CELL, 2008, 14 (03) :250-262
[8]   Inhibitors of the heat shock response: Biology and pharmacology [J].
Powers, Marissa V. ;
Workman, Paul .
FEBS LETTERS, 2007, 581 (19) :3758-3769
[9]   Targeting HSP70 The second potentially druggable heat shock protein and molecular chaperone? [J].
Powers, Marissa V. ;
Jones, Keith ;
Barillari, Caterina ;
Westwood, Isaac ;
van Montfort, Rob L. M. ;
Workman, Paul .
CELL CYCLE, 2010, 9 (08) :1542-1550