Heat Shock Protein 70 (Hsp70) as an Emerging Drug Target

被引：340

作者：

Evans, Christopher G.

Chang, Lyra

Gestwicki, Jason E. ^{[1
]}

机构：

[1] Univ Michigan, Dept Pathol, Ann Arbor, MI 48109 USA

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2010年 / 53卷 / 12期

关键词：

HEAT-SHOCK PROTEINS; N-TERMINAL KINASE; IMMUNOSUPPRESSIVE ACTIVITY RELATIONSHIPS; ANDROGEN RECEPTOR PROTEIN; CO-CHAPERONE HOP; MOLECULAR CHAPERONES; IN-VITRO; ATPASE ACTIVITY; CANCER-CELLS; ANTITUMOR-ACTIVITY;

D O I：

10.1021/jm100054f

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

[No abstract available]

引用

页码：4585 / 4602

页数：18

共 243 条

[1]

Adachi H, 2003, J NEUROSCI, V23, P2203

[2] CHIP overexpression reduces mutant androgen receptor protein and ameliorates phenotypes of the spinal and bulbar muscular atrophy transgenic mouse model [J].

Adachi, Hiroaki ;

Waza, Masahiro ;

Tokui, Keisuke ;

Katsuno, Masahisa ;

Minamiyama, Makoto ;

Tanaka, Fumiaki ;

Doyu, Manabu ;

Sobue, Gen .

JOURNAL OF NEUROSCIENCE, 2007, 27 (19) :5115-5126

[3] Heat-shock protein 70 can replace viral protein R of HIV-1 during nuclear import of the viral preintegration complex [J].

Agostini, I ;

Popov, S ;

Li, JH ;

Dubrovsky, L ;

Hao, T ;

Bukrinsky, M .

EXPERIMENTAL CELL RESEARCH, 2000, 259 (02) :398-403

[4] CHIP protects from the neurotoxicity of expanded and wild-type ataxin-1 and promotes their ubiquitination and degradation [J].

Al-Ramahi, Ismael ;

Lam, Yung C. ;

Chen, Hung-Kai ;

de Gouyon, Beatrice ;

Zhang, Minghang ;

Perez, Alma M. ;

Branco, Joana ;

de Haro, Maria ;

Patterson, Cam ;

Zoghbi, Huda Y. ;

Botas, Juan .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (36) :26714-26724

[5] Deoxyspergualin prophylaxis with tacrolimus further improves long-term graft survival in living-related renal-transplant recipients transfused with donor-specific blood [J].

Amada, N ;

Okazaki, H ;

Sato, T ;

Ohashi, Y ;

Kikuchi, H .

TRANSPLANTATION PROCEEDINGS, 2005, 37 (02) :927-929

[6] Chaperone suppression of α-synuclein toxicity in a Drosophila model for Parkinson's disease [J].

Auluck, PK ;

Chan, HYE ;

Trojanowski, JQ ;

Lee, VMY ;

Bonini, NM .

SCIENCE, 2002, 295 (5556) :865-868

[7]

Bagatell R, 2000, CLIN CANCER RES, V6, P3312

[8] Molecular chaperones enhance the degradation of expanded polyglutamine repeat androgen receptor in a cellular model of spinal and bulbar muscular atrophy [J].

Bailey, CK ;

Andriola, IFM ;

Kampinga, HH ;

Merry, DE .

HUMAN MOLECULAR GENETICS, 2002, 11 (05) :515-523

[9] Tau-mediated neurodegeneration in Alzheimer's disease and related disorders [J].

Ballatore, Carlo ;

Lee, Virginia M. -Y. ;

Trojanowski, John Q. .

NATURE REVIEWS NEUROSCIENCE, 2007, 8 (09) :663-672

[10]

Ballinger CA, 1999, MOL CELL BIOL, V19, P4535

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