Temperature-Responsive Polymer Brushes Switching from Bactericidal to Cell-Repellent

被引：133

作者：

Laloyaux, Xavier ^{[1
]}

Fautre, Emilie ^{[1
]}

Blin, Thomas ^{[2
,3
]}

Purohit, Viswas ^{[2
,3
]}

Leprince, Jerome ^{[4
]}

Jouenne, Thierry ^{[2
,3
]}

Jonas, Alain M. ^{[1
]}

Glinel, Karine ^{[1
]}

机构：

[1] Catholic Univ Louvain, Inst Condensed Matter & Nanosci Bio & Soft Matter, B-1348 Louvain, Belgium

[2] Univ Rouen, Lab Polymeres, UMR 6270, F-76821 Mont St Aignan, France

[3] Univ Rouen, FR 3038, F-76821 Mont St Aignan, France

[4] Univ Rouen, INSERM, U982, Lab Differenciat & Commun Neuronale & Neuroendocr, F-76821 Mont St Aignan, France

来源：

ADVANCED MATERIALS | 2010年 / 22卷 / 44期

关键词：

ANTIMICROBIAL PEPTIDES; POLY(N-ISOPROPYLACRYLAMIDE); ANTIBACTERIAL; SURFACE; CYTOTOXICITY; METHACRYLATE; TRANSITIONS;

D O I：

10.1002/adma.201002538

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The composition of temperature-responsive copolymer brushes based on oligo(ethylene glycol) methacrylates is tuned to obtain a collapse temperature of approximate to 35 degrees C. The chains are grafted by antibacterial magainin I peptide, whose activity is tested at different temperatures against various bacteria. The brushes switch from bactericidal to cell-repellent below and slightly above 35 degrees C, respectively, due to the progressive vertical collapse of the brush.

引用

页码：5024 / +

页数：6

共 34 条

[1] Cytotoxicity and Genotoxicity of Silver Nanoparticles in Human Cells [J].