mda-7/IL-24: A unique member of the IL-10 gene family promoting cancer-targeted toxicity

被引：133

作者：

Dash, Rupesh

Bhutia, Sujit K.

Azab, Belal

Su, Zhao-zhong

Quinn, Bridget A.

Kegelmen, Timothy P.

Das, Swadesh K.

Kim, Keetae

Lee, Seok-Geun ^{[5
]}

Park, Margaret A. ^{[2
]}

Yacoub, Adly ^{[2
,4
]}

Rahmani, Mohammed ^{[3
]}

Emdad, Luni ^{[6
,7
]}

Dmitriev, Igor P. ^{[8
]}

Wang, Xiang-Yang

Sarkar, Devanand

Grant, Steven ^{[3
]}

Dent, Paul ^{[2
,4
]}

Curiel, David T. ^{[8
]}

Fisher, Paul B. ^{[1
]}

机构：

[1] Virginia Commonwealth Univ, Sch Med, Dept Human & Mol Genet, VCU Inst Mol Med,VCU Massey Canc Ctr, Richmond, VA 23298 USA

[2] Virginia Commonwealth Univ, Sch Med, Dept Biochem & Mol Biol, Richmond, VA 23298 USA

[3] Virginia Commonwealth Univ, Sch Med, Dept Med, Richmond, VA 23298 USA

[4] Virginia Commonwealth Univ, Sch Med, Dept Neurosurg, Richmond, VA 23298 USA

[5] Kyung Hee Univ, Coll Oriental Med, Canc Prevent Mat Dev Res Ctr, Seoul, South Korea

[6] Mt Sinai Sch Med, Dept Neurosurg, New York, NY USA

[7] Mt Sinai Sch Med, Dept Oncol Sci, New York, NY USA

[8] Univ Alabama Birmingham, Gene Therapy Ctr, Birmingham, AL USA

来源：

CYTOKINE & GROWTH FACTOR REVIEWS | 2010年 / 21卷 / 05期

基金：

美国国家卫生研究院;

关键词：

mda-7/IL-24; Apoptosis; Autophagy; Bystander antitumor activity; Cancer terminator virus; DIFFERENTIATION-ASSOCIATED GENE-7; HUMAN LUNG-CANCER; PERK-DEPENDENT REGULATION; HUMAN-MELANOMA CELLS; HUMAN GLIOMA-CELLS; ENHANCES THERAPEUTIC ACTIVITY; HUMAN OVARIAN-CANCER; PROTEIN-KINASE PKR; MDA-7; GENE; PANCREATIC-CANCER;

D O I：

10.1016/j.cytogfr.2010.08.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Melanoma differentiation associated gene-7/interleukin-24 (mda-7/IL-24) is a unique member of the IL-10 gene family that displays nearly ubiquitous cancer-specific toxicity, with no harmful effects toward normal cells or tissues. mda-7/IL-24 was cloned from human melanoma cells by differentiation induction subtraction hybridization (DISH) and promotes endoplasmic reticulum (ER) stress culminating in apoptosis or toxic autophagy in a broad-spectrum of human cancers, when assayed in cell culture, in vivo in human tumor xenograft mouse models and in a Phase I clinical trial in patients with advanced cancers. This therapeutically active cytokine also induces indirect antitumor activity through inhibition of angiogenesis, stimulation of an antitumor immune response, and sensitization of cancer cells to radiation-, chemotherapy- and antibody-induced killing. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：381 / 391

页数：11

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