Biomimetic transfer hydrogenation of 2-alkoxy- and 2-aryloxyketones with iron-porphyrin catalysts

被引：53

作者：

Enthaler, Stephan ^{[1
]}

Spilker, Bjoern ^{[1
]}

Erre, Giulia ^{[1
]}

Junge, Kathrin ^{[1
]}

Tse, Man Kin ^{[1
]}

Beller, Matthias ^{[1
]}

机构：

[1] Univ Rostock, Leibniz Inst Katalyse eV, D-18059 Rostock, Germany

来源：

TETRAHEDRON | 2008年 / 64卷 / 17期

关键词：

D O I：

10.1016/j.tet.2008.01.083

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In situ generated iron porphyrins are applied as homogeneous catalysts in the transfer hydrogenation of a-substituted ketones. Using 2-propanol as hydrogen donor various protected 1, 2-hydroxyketones are reduced to the corresponding mono-substituted 1,2-diols in good to excellent yield. Under optimized reaction conditions catalyst turnover frequencies up to 2500 h(-1) have been achieved. (c) 2008 Elsevier Ltd. All rights reserved.

引用

收藏

页码：3867 / 3876

页数：10

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