Kinetic and chemical mechanism of epoxide hydrolase

被引:35
作者
Armstrong, RN [1 ]
机构
[1] Vanderbilt Univ, Sch Med, Dept Biochem, Nashville, TN 37232 USA
[2] Vanderbilt Univ, Sch Med, Dept Chem, Nashville, TN 37232 USA
[3] Vanderbilt Univ, Sch Med, Ctr Mol Toxicol, Nashville, TN 37232 USA
关键词
D O I
10.1081/DMR-100101908
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
引用
收藏
页码:71 / 86
页数:16
相关论文
共 36 条
[31]   Semifunctional site-specific mutants affecting the hydrolytic half-reaction of microsomal epoxide hydrolase [J].
Tzeng, HF ;
Laughlin, LT ;
Armstrong, RN .
BIOCHEMISTRY, 1998, 37 (09) :2905-2911
[32]   The catalytic mechanism of microsomal epoxide hydrolase involves reversible formation and rate-limiting hydrolysis of the alkyl-enzyme intermediate [J].
Tzeng, HF ;
Laughlin, LT ;
Lin, S ;
Armstrong, RN .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1996, 118 (39) :9436-9437
[33]  
TZENG HF, UNPUB
[34]   ACTIVE-SITE ZINC LIGANDS AND ACTIVATED H2O OF ZINC ENZYMES [J].
VALLEE, BL ;
AULD, DS .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (01) :220-224
[35]   CRYSTALLOGRAPHIC AND FLUORESCENCE STUDIES OF THE INTERACTION OF HALOALKANE DEHALOGENASE WITH HALIDE-IONS - STUDIES WITH HALIDE COMPOUNDS REVEAL A HALIDE BINDING-SITE IN THE ACTIVE-SITE [J].
VERSCHUEREN, KHG ;
KINGMA, J ;
ROZEBOOM, HJ ;
KALK, KH ;
JANSSEN, DB ;
DIJKSTRA, BW .
BIOCHEMISTRY, 1993, 32 (35) :9031-9037
[36]   CRYSTALLOGRAPHIC ANALYSIS OF THE CATALYTIC MECHANISM OF HALOALKANE DEHALOGENASE [J].
VERSCHUEREN, KHG ;
SELJEE, F ;
ROZEBOOM, HJ ;
KALK, KH ;
DIJKSTRA, BW .
NATURE, 1993, 363 (6431) :693-698