Negative regulation of Wingless signaling by D-axin, a Drosophila homolog of axin

被引：173

作者：

Hamada, F

Tomoyasu, Y

Takatsu, Y

Nakamura, M

Nagai, S

Suzuki, A

Fujita, F

Shibuya, H

Toyoshima, K

Ueno, N

Akiyama, T

机构：

[1] Osaka Univ, Res Inst Microbial Dis, Dept Oncogene Res, Suita, Osaka 5650871, Japan

[2] Japan Sci & Technol Corp, PRESTO, Inheritance & Variat Precursory Res Embryon Sci &, Kyoto, Japan

[3] Natl Inst Basic Biol, Dept Dev Biol, Okazaki, Aichi 4448585, Japan

[4] Osaka Med Ctr Canc & Cardiovasc Dis, Higashinari Ku, Osaka 5378511, Japan

[5] Univ Tokyo, Inst Mol & Cellular Biosci, Dept Mol & Genet Informat, Bunkyo Ku, Tokyo 1130032, Japan

来源：

SCIENCE | 1999年 / 283卷 / 5408期

关键词：

D O I：

10.1126/science.283.5408.1739

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Wnt/Wingless directs many cell fates during development. Wnt/Wingless signaling increases the amount of beta-catenin/Armadillo, which in turn activates gene transcription. Here the Drosophila protein D-Axin was shown to interact with Armadillo and D-APC. Mutation of d-axin resulted in the accumulation of cytoplasmic Armadillo and one of the Wingless target gene products, Distal-less. Ectopic expression of d-axin inhibited Wingless signaling. Hence, D-Axin negatively regulates Wingless signaling by down-regulating the Level of Armadillo. These results establish the importance of the Axin family of proteins in Wnt/Wingless signaling in Drosophila.

引用

页码：1739 / 1742

页数：4

共 34 条

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