Label-free electronic detection of DNA using simple double-walled carbon nanotube resistors

被引：37

作者：

Dong, Xiaochen ^{[1
,2
]}

Fu, Dongliang ^{[1
]}

Xu, Yanping ^{[1
]}

Wei, Jinquan ^{[4
]}

Shi, Yumeng ^{[1
]}

Chen, Peng ^{[3
]}

Li, Lain-Jong ^{[1
]}

机构：

[1] Nanyang Technol Univ, Sch Mat Sci & Engn, Singapore 637819, Singapore

[2] Nanjing Univ Posts & Telecommun, IAM, Nanjing 210046, Peoples R China

[3] Nanyang Technol Univ, Sch Chem & Biomed Engn, Singapore 637819, Singapore

[4] Tsinghua Univ, Educ Minist, Key Lab AMMPT, Beijing 100084, Peoples R China

来源：

JOURNAL OF PHYSICAL CHEMISTRY C | 2008年 / 112卷 / 26期

关键词：

D O I：

10.1021/jp7121714

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Label-free electrical detection of DNA hybridization using resistive sensing devices based on drop-casted doubled-walled carbon nanotube (DWNT) networks and as-grown films is presented. Sensitive, selective, and reliable detection of DNA hybridization is achieved by simple two-terminal measurements, which is suitable for the hand-held type of device applications. Our approach is able to detect DNA concentrations ranging from 50 to 500 nM. Utilizing location-selective capping by photoresists, we designed experiments to reveal the sensing mechanism and found that the carbon nanotube (CNT)-metal junction may not play a dominant role in sensing as it does in single-walled carbon nanotube-based transistor devices. A charge-transfer model is proposed to explain the detection mechanism.

引用

页码：9891 / 9895

页数：5