UBX domain proteins: major regulators of the AAA ATPase Cdc48/p97

被引：227

作者：

Schuberth, C. ^{[1
]}

Buchberger, A. ^{[2
]}

机构：

[1] EMBL Heidelberg, Biol & Biophys Unit, D-69117 Heidelberg, Germany

[2] Max Planck Inst Biochem, Dept Mol Cell Biol, D-82152 Martinsried, Germany

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2008年 / 65卷 / 15期

关键词：

AAA ATPase; valosin-containing protein (VCP); ubiquitin; proteasome system; protein degradation; UBA domain; ubiquitin-like fold;

D O I：

10.1007/s00018-008-8072-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The highly conserved AAA ATPase Cdc48/p97 acts on ubiquitylated substrate proteins in cellular processes as diverse as the fusion of homotypic membranes and the degradation of misfolded proteins. The 'Ubiquitin regulatory X' (UBX) domain-containing proteins constitute the so far largest family of Cdc48/p97 cofactors. UBX proteins are involved in substrate recruitment to Cdc48/p97 and in the temporal and spatial regulation of its activity. In combination with UBX-like proteins and other cofactors, they can assemble into a large variety of Cdc48/p97-cofactor complexes possessing distinct cellular functions. This review gives an overview of the different subfamilies of UBX proteins and their functions, and discusses general principles of Cdc48/p97 regulation by these cofactors.

引用

页码：2360 / 2371

页数：12

共 99 条

[1] The PUB domain functions as a p97 binding module in human peptide N-glycanase [J].

Allen, Mark D. ;

Buchberger, Alexander ;

Bycroft, Mark .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (35) :25502-25508

[2] Nuclear envelope formation by chromatin-mediated reorganization of the endoplasmic reticulum [J].

Anderson, Daniel J. ;

Hetzer, Martin W. .

NATURE CELL BIOLOGY, 2007, 9 (10) :1160-1166

[3] Identification of SVIP as an endogenous inhibitor of endoplasmic reticulum-associated degradation [J].

Ballar, Petek ;

Zhong, Yongwang ;

Nagahama, Masami ;

Tagaya, Mitsuo ;

Shen, Yuxian ;

Fang, Shengyun .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (47) :33908-33914

[4] The role of a novel p97/valosin-containing protein-interacting motif of gp78 in endoplasmic reticulum-associated degradation [J].

Ballar, Petek ;

Shen, Yuxian ;

Yang, Hui ;

Fang, Shengyun .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (46) :35359-35368

[5] HRD4/NPL4 is required for the proteasomal processing of ubiquitinated ER proteins [J].

Bays, NW ;

Wilhovsky, SK ;

Goradia, A ;

Hodgkiss-Harlow, K ;

Hampton, RY .

MOLECULAR BIOLOGY OF THE CELL, 2001, 12 (12) :4114-4128

[6] Conformational changes in the AAA ATPase p97-p47 adaptor complex [J].

Beuron, Fabienne ;

Dreveny, Ingrid ;

Yuan, Xuemei ;

Pye, Valerie E. ;

McKeown, Ciaran ;

Briggs, Louise C. ;

Cliff, Matthew J. ;

Kaneko, Yayoi ;

Wallis, Russell ;

Isaacson, Rivka L. ;

Ladbury, John E. ;

Matthews, Steve J. ;

Kondo, Hisao ;

Zhang, Xiaodong ;

Freemont, Paul S. .

EMBO JOURNAL, 2006, 25 (09) :1967-1976

[7] Functional cloning of TUG as a regulator of GLUT4 glucose transporter trafficking [J].

Bogan, JS ;

Hendon, N ;

McKee, AE ;

Tsao, TS ;

Lodish, HF .

NATURE, 2003, 425 (6959) :727-733

[8] Role of the ubiquitin-selective CDC48UFD1/NPL4 chaperone (segregase) in ERAD of OLE1 and other substrates [J].

Braun, S ;

Matuschewski, K ;

Rape, M ;

Thoms, S ;

Jentsch, S .

EMBO JOURNAL, 2002, 21 (04) :615-621

[9] The AAA ATPase p97/VCP interacts with its alternative co-factors, Ufd1-Npl4 and p47, through a common bipartite binding mechanism [J].

Bruderer, RM ;

Brasseur, C ;

Meyer, HH .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (48) :49609-49616

[10] From UBA to UBX: new words in the ubiquitin vocabulary [J].

Buchberger, A .

TRENDS IN CELL BIOLOGY, 2002, 12 (05) :216-221

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