Filovirus Hemorrhagic Fever Outbreak Case Management: A Review of Current and Future Treatment Options

被引:26
作者
Roddy, Paul [1 ]
Colebunders, Robert [2 ,3 ]
Jeffs, Benjamin [1 ]
Palma, Pedro Pablo [1 ]
Van Herp, Michel [4 ]
Borchert, Matthias [5 ]
机构
[1] Med Sans Frontieres Spain, Barcelona, Spain
[2] Inst Trop Med, B-2000 Antwerp, Belgium
[3] Univ Antwerp, B-2020 Antwerp, Belgium
[4] Med Sans Frontieres Belgium, Brussels, Belgium
[5] Charite, Inst Trop Med & Int Hlth, D-13353 Berlin, Germany
关键词
SANS-FRONTIERES INTERVENTION; EBOLA-VIRUS INFECTION; ACTIVATED PROTEIN-C; POSTEXPOSURE PROTECTION; RNA INTERFERENCE; SEVERE SEPSIS; HEALTH-CARE; MARBURG; ANTISENSE; EPIDEMIC;
D O I
10.1093/infdis/jir297
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
We describe and discuss treatment possibilities, challenges, and potential next steps for FHF outbreak case management. More comprehensive supportive treatment, including vital sign monitoring, intensive care components, and goal-directed interventions may contribute to improved clinical outcome; the feasibility and effectiveness of this more comprehensive supportive treatment should be assessed. Our outlined summary may assist future FHF outbreak case management teams to create collaborative platforms and develop relevant treatment protocols aimed at improving clinical outcome.
引用
收藏
页码:S791 / S795
页数:5
相关论文
共 45 条
[31]  
MUPAPA K, 1999, J INFECT DIS S1, V179, pS118
[32]   Epidemiologic and clinical aspects of the Ebola virus epidemic in Mosango, Democratic Republic of the Congo, 1995 [J].
Ndambi, R ;
Akamituna, P ;
Bonnet, MJ ;
Tukadila, AM ;
Muyembe-Tamfum, JJ ;
Colebunders, R .
JOURNAL OF INFECTIOUS DISEASES, 1999, 179 :S8-S10
[33]   Infection control during filoviral hemorrhagic fever outbreaks: preferences of community members and health workers in Masindi, Uganda [J].
Raabe, Vanessa N. ;
Mutyaba, Imaam ;
Roddy, Paul ;
Lutwama, Julius J. ;
Geissler, Wenzel ;
Borchert, Matthias .
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 2010, 104 (01) :48-50
[34]   The medecins sans frontieres intervention in the Marburg hemorrhagic fever epidemic, Uige, Angola, 2005. II. lessons learned in the community [J].
Roddy, Paul ;
Weatherill, David ;
Jeffs, Benjamin ;
Abaakouk, Zohra ;
Dorion, Claire ;
Rodriguez-Martinez, Josefa ;
Palma, Pedro Pablo ;
de la Rosa, Olimpia ;
Villa, Luis ;
Grovas, Isabel ;
Borchert, Matthias .
JOURNAL OF INFECTIOUS DISEASES, 2007, 196 :S162-S167
[35]  
Sanchez A., 2007, FIELDS VIROLOGY, P1409
[36]   Oligonucleotide antiviral therapeutics: Antisense and RNA interference for highly pathogenic RNA viruses [J].
Spurgers, Kevin B. ;
Sharkey, C. Matthew ;
Warfield, Kelly L. ;
Bavari, Sina .
ANTIVIRAL RESEARCH, 2008, 78 (01) :26-36
[37]  
STERK E, 2008, FILOVIRUS HAEMORRHAG, P1
[38]   Chemical Modifications of Antisense Morpholino Oligomers Enhance Their Efficacy against Ebola Virus Infection [J].
Swenson, Dana L. ;
Warfield, Kelly L. ;
Warren, Travis K. ;
Lovejoy, Candace ;
Hassinger, Jed N. ;
Ruthel, Gordon ;
Blouch, Robert E. ;
Moulton, Hong M. ;
Weller, Dwight D. ;
Iversen, Patrick L. ;
Bavari, Sina .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2009, 53 (05) :2089-2099
[39]   Epidemiology of needlestick injuries among health-care workers in Awassa City, Southern Ethiopia [J].
Tadesse, Moges ;
Tadesse, Takele .
TROPICAL DOCTOR, 2010, 40 (02) :111-113
[40]  
Warfield Kelly L., 2006, PLoS Pathogens, V2, P5