Targeting Regulatory T Cells in Cancer

被引：149

作者：

Byrne, William L. ^{[1
,2
]}

Mills, Kingston H. G. ^{[3
]}

Lederer, James A. ^{[4
,5
]}

O'Sullivan, Gerald C. ^{[1
,2
]}

机构：

[1] Univ Coll Cork, Mercy Univ Hosp, Cork Canc Res Ctr, Cork, Ireland

[2] Univ Coll Cork, Leslie C Quick Jnr Lab, Cork, Ireland

[3] Trinity Coll Dublin, Sch Biochem & Immunol, Immune Regulat Res Grp, Dublin, Ireland

[4] Brigham & Womens Hosp, Dept Surg Immunol, Boston, MA 02115 USA

[5] Harvard Univ, Sch Med, Boston, MA USA

来源：

CANCER RESEARCH | 2011年 / 71卷 / 22期

基金：

爱尔兰科学基金会;

关键词：

TUMOR-IMMUNITY; REGRESSION; DEPLETION; MELANOMA;

D O I：

10.1158/0008-5472.CAN-11-1156

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Infiltration of tumors by regulatory T cells confers growth and metastatic advantages by inhibiting antitumor immunity and by production of receptor activator of NF-kappa B (RANK) ligand, which may directly stimulate metastatic propagation of RANK-expressing cancer cells. Modulation of regulatory T cells can enhance the efficacy of cancer immunotherapy. Strategies include depletion, interference with function, inhibition of tumoral migration, and exploitation of T-cell plasticity. Problems with these strategies include a lack of specificity, resulting in depletion of antitumor effector T cells or global interruption of regulatory T cells, which may predispose to autoimmune diseases. Emerging technologies, such as RNA interference and tetramer-based targeting, may have the potential to improve selectivity and efficacy. Cancer Res; 71(22); 6915-20. (C)2011 AACR.

引用

页码：6915 / 6920

页数：6

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