Iridoid glycosides isolated from Oldenlandia diffusa inhibit LDL-oxidation

被引：89

作者：

Kim, DH

Lee, HJ

Oh, YJ

Kim, MJ

Kim, SH

Jeong, TS

Baek, NI

机构：

[1] Kyung Hee Univ, Grad Sch Biotechnol, Suwon 449701, South Korea

[2] Kyung Hee Univ, Plant Metab Res Ctr, Suwon 449701, South Korea

[3] Kyung Hee Univ, Grad Sch EW Med Sci, Suwon 449701, South Korea

[4] Korea Res Inst Biosci & Biotechnol, Taejon 305333, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2005年 / 28卷 / 10期

关键词：

Oldenlandia diffusa; Rubiaceae; iridoid; oldenlandoside III; LDL-oxidation inhibition;

D O I：

10.1007/BF02972979

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

An iridoid glycoside, oldenlandoside III (5) was isolated from the n-butanol fraction of methanol extracts of the aerial parts of Oldenlandia diffusa Roxb. along with six others previously characterized iridoid glycosides; geniposidic acid (1), scandoside (2), feretoside (3), 10-O-benzoylscandoside methyl ester (4), asperulosidic acid (6) and deacetylasperulosidic acid (7). Compounds 1, 2, and 7 inhibited LDL-oxidation, and showed 63.3 +/- 2.0, 62.2 +/- 1.6, and 63.8 +/- 1.5% inhibition, respectively, at a concentration of 20 mu g/mL.

引用

收藏

页码：1156 / 1160

页数：5

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