Calcitonin gene-related peptide level in the rat dentate gyrus increases after damage

被引：25

作者：

Bulloch, K ^{[1
]}

Prasad, A ^{[1
]}

Conrad, CD ^{[1
]}

McEwen, BS ^{[1
]}

Milner, TA ^{[1
]}

机构：

[1] CORNELL UNIV,COLL MED,DEPT NEUROL & NEUROSCI,NEW YORK,NY 10021

来源：

NEUROREPORT | 1996年 / 7卷 / 05期

关键词：

CGRP; dentate gyrus damage; mossy cells; molecular layer; hippocampus;

D O I：

10.1097/00001756-199604100-00016

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

CALCITONIN gene related peptide-like immunoreactivity (CGRP-LI) was examined in rat dentate gyrus (DG) following damage to granule cells by adrenalectomy or intrahippocampal colchicine injections. In normal DG, CGRP-LI was present in a diffuse Land within the inner third of the molecular layer (ITML) and in hilar cells. Following the experimental procedures, levels of CGRP-LI increased bilaterally in the ITML and in hilar interneurons resembling messy cells. Ultrastructural analysis of the ITML revealed that CGRP-LI is associated with large, dense-core vesicles within axon terminals which form asymmetrical synapses with dendritic spines, and within dendritic spines. The increase in CGRP-LI level following granule cell damage suggests a protective role for CGRP in the response to hippocampal injury.

引用

页码：1036 / 1040

页数：5

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