Simultaneous PET-MRI:: a new approach for functional and morphological imaging

被引：715

作者：

Judenhofer, Martin S. ^{[1
]}

Wehrl, Hans F. ^{[1
]}

Newport, Danny F. ^{[2
]}

Catana, Ciprian ^{[3
]}

Siegel, Stefan B. ^{[2
]}

Becker, Markus ^{[4
]}

Thielscher, Axel ^{[5
]}

Kneilling, Manfred ^{[6
]}

Lichy, Matthias P. ^{[1
]}

Eichner, Martin ^{[7
]}

Klingel, Karin ^{[8
]}

Reischl, Gerald ^{[9
]}

Widmaier, Stefan ^{[4
]}

Roecken, Martin ^{[6
]}

Nutt, Robert E. ^{[2
]}

Machulla, Hans-Juergen ^{[9
]}

Uludag, Kamil ^{[5
]}

Cherry, Simon R. ^{[3
]}

Claussen, Claus D. ^{[1
]}

Pichler, Bernd J. ^{[1
]}

机构：

[1] Univ Tubingen, Dept Radiol, Lab Preclin Imaging & Imaging Tech Werner Siemens, D-72076 Tubingen, Germany

[2] Siemens Preclin Solut, Knoxville, TN 37932 USA

[3] Univ Calif Davis, Dept Biomed Engn, Davis, CA 95616 USA

[4] Bruker BioSpin MRI GmbH, D-76275 Ettingen, Germany

[5] Max Planck Inst Biol Cybernet, D-72076 Tubingen, Germany

[6] Univ Tubingen, Dermatol Clin, D-72076 Tubingen, Germany

[7] Univ Tubingen, Dept Med Biometry, D-72070 Tubingen, Germany

[8] Univ Tubingen, Inst Pathol, Dept Mol Pathol, D-72076 Tubingen, Germany

[9] Univ Tubingen, PET Ctr, D-72076 Tubingen, Germany

来源：

NATURE MEDICINE | 2008年 / 14卷 / 04期

关键词：

D O I：

10.1038/nm1700

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Noninvasive imaging at the molecular level is an emerging field in biomedical research. This paper introduces a new technology synergizing two leading imaging methodologies: positron emission tomography ( PET) and magnetic resonance imaging ( MRI). Although the value of PET lies in its high- sensitivity tracking of biomarkers in vivo, it lacks resolving morphology. MRI has lower sensitivity, but produces high soft- tissue contrast and provides spectroscopic information and functional MRI ( fMRI). We have developed a three- dimensional animal PET scanner that is built into a 7- T MRI. Our evaluations show that both modalities preserve their functionality, even when operated isochronously. With this combined imaging system, we simultaneously acquired functional and morphological PET- MRI data from living mice. PET- MRI provides a powerful tool for studying biology and pathology in preclinical research and has great potential for clinical applications. Combining fMRI and spectroscopy with PET paves the way for a new perspective in molecular imaging.

引用

页码：459 / 465

页数：7

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