Lack of somatic mutation in the PTEN gene in squamous cell carcinomas of human skin

被引：24

作者：

Kubo, Y ^{[1
]}

Urano, Y ^{[1
]}

Hida, Y ^{[1
]}

Arase, S ^{[1
]}

机构：

[1] Univ Tokushima, Sch Med, Dept Dermatol, Tokushima 7708503, Japan

来源：

JOURNAL OF DERMATOLOGICAL SCIENCE | 1999年 / 19卷 / 03期

关键词：

PTEN; MMAC1; TEP1; carcinogenesis; allelic polymorphism;

D O I：

10.1016/S0923-1811(98)00058-9

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

The tumor suppressor gene PTEN is deleted and/or mutated in a variety of tumors and the susceptibility gene for Cowden disease. Loss of heterozygosity of chromosome 10q23, where PTEN resides, in squamous cell carcinomas (SCCs) of human skin and the association of SCC with Cowden disease were reported previously. In the present study, we screened for mutations of PTEN in SCCs by polymerase chain reaction-single strand conformation polymorphism analysis to examine whether PTEN is involved in the carcinogenesis of SCC. None of 21 SCCs showed somatic mutations in the coding regions of PTEM. Instead the same allelic variation was detected in two cases without any clinical features of Cowden disease. Our results indicate that inactivation of PTEN does not play an important role in the carcinogenesis of SCC. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：199 / 201

页数：3

共 13 条

[1]

ENG C, 1998, GENETIC BASIS HUMAN, P519

[2] Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domain [J].

Furnari, FB ;

Lin, H ;

Huang, HJS ;

Cavenee, WK .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (23) :12479-12484

[3] Mutations of the INK4a locus in squamous cell carcinomas of human skin [J].

Kubo, Y ;

Urano, Y ;

Matsumoto, K ;

Ahsan, K ;

Arase, S .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1997, 232 (01) :38-41

[4] P53 GENE-MUTATIONS IN HUMAN SKIN CANCERS AND PRECANCEROUS LESIONS - COMPARISON WITH IMMUNOHISTOCHEMICAL ANALYSIS [J].

KUBO, Y ;

URANO, Y ;

YOSHIMOTO, K ;

IWAHANA, H ;

FUKUHARA, K ;

ARASE, S ;

ITAKURA, M .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1994, 102 (04) :440-444

[5]

Li DM, 1997, CANCER RES, V57, P2124

[6] PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer [J].

Li, J ;

Yen, C ;

Liaw, D ;

Podsypanina, K ;

Bose, S ;

Wang, SI ;

Puc, J ;

Miliaresis, C ;

Rodgers, L ;

McCombie, R ;

Bigner, SH ;

Giovanella, BC ;

Ittmann, M ;

Tycko, B ;

Hibshoosh, H ;

Wigler, MH ;

Parsons, R .

SCIENCE, 1997, 275 (5308) :1943-1947

[7] Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome [J].

Liaw, D ;

Marsh, DJ ;

Li, J ;

Dahia, PLM ;

Wang, SI ;

Zheng, ZM ;

Bose, S ;

Call, KM ;

Tsou, HC ;

Peacocke, M ;

Eng, C ;

Parsons, R .

NATURE GENETICS, 1997, 16 (01) :64-67

[8] MULTIPLE HAMARTOMA SYNDROME (COWDENS DISEASE) [J].

NUSS, DD ;

AELING, JL ;

CLEMONS, DE ;

WEBER, WN .

ARCHIVES OF DERMATOLOGY, 1978, 114 (05) :743-746

[9]

QUINN AG, 1994, CANCER RES, V54, P4756

[10] Infrequent genetic alterations of the PTEN/MMAC1 gene in Japanese patients with primary cancers of the breast, lung, pancreas, kidney, and ovary [J].

Sakurada, A ;

Suzuki, A ;

Sato, M ;

Yamakawa, H ;

Orikasa, K ;

Uyeno, S ;

Ono, T ;

Ohuchi, N ;

Fujimura, S ;

Horii, A .

JAPANESE JOURNAL OF CANCER RESEARCH, 1997, 88 (11) :1025-1028

← 1 2 →