Insight into the genetic epidemiology of coronary heart disease

被引：6

作者：

Cambien, F

机构：

来源：

ANNALS OF MEDICINE | 1996年 / 28卷 / 05期

关键词：

candidate genes; coronary heart disease; gene-environment interaction; gene-gene interaction; genetic polymorphism;

D O I：

10.3109/07853899608999109

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The associations between candidate gene polymorphisms and coronary heart disease (CHD) are complex as a consequence of pleiotropy, variation with age, selection due to the high lethality of the disease, and interactions with other genes and with environmental factors. Identification of the gene variants that contribute to CHD appears possible; this may considerably improve our understanding of the aetiology and mechanisms of this disease, Furthermore, simultaneous analysis of several predisposing alleles may help to identify high-risk individuals.

引用

页码：465 / 470

页数：6

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