Diblydropyrido[2,3-d]pyrimidines as a new class of antfleishmanial agents

被引：138

作者：

Agarwal, A

Ramesh

Ashutosh

Goyal, N

Chauhan, PMS ^{[1
]}

Gupta, S

机构：

[1] Cent Drug Res Inst, Div Med Chem, Lucknow 226001, Uttar Pradesh, India

[2] Cent Drug Res Inst, Div Parasitol, Lucknow 226001, Uttar Pradesh, India

[3] Cent Drug Res Inst, Div Biochem, Lucknow 226001, Uttar Pradesh, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2005年 / 13卷 / 24期

关键词：

lieshmania; dihydrofolate reductase; dihydropyrido[2,3d]pyrimidine; uracil;

D O I：

10.1016/j.bmc.2005.07.043

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

A series of dihydropyrido[2,3-d]pyrimidines have been synthesized and screened for its in vitro antileishmanial activity profile in promastigote and amastigote models. Compounds 2a-2l have shown 83-100% inhibition against promastigotes and 79-100% inhibition against amastigotes at a concentration of 50 mu g/mL. (c) 2005 Elsevier Ltd. All rights reserved.

引用

收藏

页码：6678 / 6684

页数：7

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