Executive dysfunction in spinocerebellar ataxia type 1

被引：46

作者：

Bürk, S

Bösch, S

Globas, C

Zühlke, C

Daum, I

Klockgether, T

Dichgans, J

机构：

[1] Univ Tubingen, Dept Neurol, D-72076 Tubingen, Germany

[2] Med Univ Lubeck, Dept Mol Genet, D-23538 Lubeck, Germany

[3] Ruhr Univ Bochum, D-4630 Bochum, Germany

[4] Univ Bonn, Dept Neurol, D-5300 Bonn, Germany

来源：

EUROPEAN NEUROLOGY | 2001年 / 46卷 / 01期

关键词：

spinocerebellar ataxia type 1 (SCA1); executive dysfunction; cerebellum; cognition;

D O I：

10.1159/000050755

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Fourteen patients with spinocerebellar ataxia 1 (SCA1) and 11 controls with similar mean age and IQ estimates were submitted to a neuropsychological test battery comprising tests for IQ, attention, verbal and visuospatial memory as well as executive functions. Neuropsychological assessment yielded verbal memory and executive dysfunction while tests of visuospatial memory and attention were not significantly impaired in SCA1 as compared to controls. Test performance was neither related to the repeat length, the age of onset nor the disease duration. The profile of cognitive impairment in SCA1 with prominent executive dysfunction corresponds to the concept of 'frontal-subcortical' dementia that is likely to be contingent upon disruption of a cerebrocerebellar circuitry that consists of afferent and efferent connections between the prefrontal cortex and the cerebellum. Copyright (C) 2001 S.Karger AG, Basel.

引用

页码：43 / 48

页数：6

共 32 条

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