The human sialyltransferase family

被引：463

作者：

Harduin-Lepers, A ^{[1
]}

Vallejo-Ruiz, V ^{[1
]}

Krzewinski-Recchi, MA ^{[1
]}

Samyn-Petit, B ^{[1
]}

Julien, S ^{[1
]}

Delannoy, P ^{[1
]}

机构：

[1] Univ Sci & Technol Lille, Chim Biol Lab, CNRS, UMR 8576,Unite Glycobiol Struct & Fonct, F-59655 Villeneuve Dascq, France

来源：

BIOCHIMIE | 2001年 / 83卷 / 08期

关键词：

human genome; sialyltransferase; sialylated glycoproteins; sialylated glycolipids; sialyltransferase cDNA;

D O I：

10.1016/S0300-9084(01)01301-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The human genome encodes probably more than 20 different sialyltransferases involved in the biosynthesis of sialylated glycoproteins and glycolipids but to date only 15 different human sialyltransferase cDNAs have been cloned and characterized. Each of the sialyltransferase genes is differentially expressed in a tissue-, cell type-, and stage-specific manner to regulate the sialylation pattern of cells. These enzymes differ in their substrate specificity, tissue distribution and various biochemical parameters. However, enzymatic analysis conducted in vitro with recombinant enzyme revealed that one linkage can be synthesized by multiple enzymes. We present here an overview of these human genes and enzymes, the regulation of their occurrence and their involvement in several physiological and pathological processes. (C) 2001 Societe francaise de biochimie et biologie moleculaire/Editions scientifiques et medicales Elsevier SAS. All rights reserved.

引用

页码：727 / 737

页数：11

共 61 条

[11] Expression cloning of mouse cDNA of CMP-NeuAc:lactosylceramide α2,3-sialyltransferase, an enzyme that initiates the synthesis of gangliosides [J].