Synergistic effects of cannabinoid inverse agonist AM251 and opioid antagonist nalmefene on food intake in mice

被引：56

作者：

Chen, RZ ^{[1
]}

Huang, RRC ^{[1
]}

Shen, CP ^{[1
]}

MacNeil, DJ ^{[1
]}

Fong, TM ^{[1
]}

机构：

[1] Merck Res Labs, Dept Metab Disorders, Rahway, NJ 07065 USA

来源：

BRAIN RESEARCH | 2004年 / 999卷 / 02期

关键词：

food intake; Nalmefene; AM251; opioid; cannabinoid;

D O I：

10.1016/j.brainres.2003.12.004

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Oral administration of the opioid antagonist nalmefene alone (up to 20 mg/kg) failed to show a significant effect on acute food intake in mice. However, combined oral dosing of nalmefene and subthreshold doses of AM251, a cannabinoid CB1 receptor inverse agonist, led to a significant reduction in food intake in both lean and diet-induced obese (DIO) mice. Furthermore, the anorectic effect of a high dose of AM251 was further enhanced when co-administered with nalmefene. The results support a synergistic interaction between opioid and cannabinoid systems in regulating feeding behavior. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：227 / 230

页数：4

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