The microbiology of asthma

被引：162

作者：

Edwards, Michael R. ^{[1
,2
,3
]}

Bartlett, Nathan W. ^{[1
,2
]}

Hussell, Tracy ^{[1
,2
]}

Openshaw, Peter ^{[1
,2
]}

Johnston, Sebastian L. ^{[1
,2
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, Ctr Resp Infect, London W2 1PG, England

[2] Univ London Imperial Coll Sci Technol & Med, MRC & Asthma UK Ctr Allerg Mech Asthma, London W2 1PG, England

[3] Univ London Imperial Coll Sci Technol & Med, Wright Fleming Inst Infect & Immun, London W2 1PG, England

来源：

NATURE REVIEWS MICROBIOLOGY | 2012年 / 10卷 / 07期

基金：

英国惠康基金; 欧洲研究理事会; 英国医学研究理事会;

关键词：

RESPIRATORY SYNCYTIAL VIRUS; BRONCHIAL EPITHELIAL-CELLS; PULMONARY DENDRITIC CELLS; WHEEZING RHINOVIRUS ILLNESSES; THYMIC STROMAL LYMPHOPOIETIN; IN-HOUSE DUST; ALLERGIC INFLAMMATION; FUNGAL SENSITIZATION; CHLAMYDIA-PNEUMONIAE; ALVEOLAR MACROPHAGES;

D O I：

10.1038/nrmicro2801

中图分类号：

Q93 [微生物学];

学科分类号：

071005 [微生物学];

摘要：

Asthma remains an important human disease that is responsible for substantial worldwide morbidity and mortality. The causes of asthma are multifactorial and include a complex mix of environmental, immunological and host genetic factors. In addition, epidemiological studies show strong associations between asthma and infection with respiratory pathogens, including common respiratory viruses such as rhinoviruses, human respiratory syncytial virus, adenoviruses, coronaviruses and influenza viruses, as well as bacteria (including atypical bacteria) and fungi. In this Review, we describe the many roles of microorganisms in the risk of developing asthma and in the pathogenesis of and protection against the disease, and we discuss the mechanisms by which infections affect the severity and prevalence of asthma.

引用

页码：459 / 471

页数：13

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