Dominant tolerance: activation thresholds for peripheral generation of regulatory T cells

被引：43

作者：

Graca, L

Chen, TC

Le Moine, A

Cobbold, SP

Howie, D

Waldmann, H

机构：

[1] Sir William Dunn Sch Pathol, Oxford OX1 3RE, England

[2] Univ Lisbon, Fac Med, P-1649028 Lisbon, Portugal

[3] Chang Gung Univ, Chang Gung Mem Hosp, Dept Pathol, Taoyuan, Taiwan

[4] Free Univ Brussels, Hop Erasme, Fac Med, Inst Med Immunol, B-1070 Brussels, Belgium

来源：

TRENDS IN IMMUNOLOGY | 2005年 / 26卷 / 03期

关键词：

D O I：

10.1016/j.it.2004.12.007

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In recent years, regulatory T (Treg) cells have reached centre-stage in immune tolerance research. A role for Treg cells in preventing autoimmunity or generating transplantation tolerance is now undisputed. However, in spite of a surge in publications dedicated to Treg cells, surprisingly little is known about their induction, biology and mechanisms of action. In this Opinion, we discuss the facts and the controversies regarding their role in transplantation tolerance. We suggest that peripheral generation of Treg cells, crucial for the generation of dominant transplantation tolerance, might be a consequence of sustained suboptimal antigenic stimulation, and that transforming growth factor-beta (TGF-beta) might contribute to this process by increasing the threshold for T-cell activation.

引用

页码：130 / 135

页数：6

共 59 条

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