Dominant tolerance: activation thresholds for peripheral generation of regulatory T cells

被引：43

作者：

Graca, L

Chen, TC

Le Moine, A

Cobbold, SP

Howie, D

Waldmann, H

机构：

[1] Sir William Dunn Sch Pathol, Oxford OX1 3RE, England

[2] Univ Lisbon, Fac Med, P-1649028 Lisbon, Portugal

[3] Chang Gung Univ, Chang Gung Mem Hosp, Dept Pathol, Taoyuan, Taiwan

[4] Free Univ Brussels, Hop Erasme, Fac Med, Inst Med Immunol, B-1070 Brussels, Belgium

来源：

TRENDS IN IMMUNOLOGY | 2005年 / 26卷 / 03期

关键词：

D O I：

10.1016/j.it.2004.12.007

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In recent years, regulatory T (Treg) cells have reached centre-stage in immune tolerance research. A role for Treg cells in preventing autoimmunity or generating transplantation tolerance is now undisputed. However, in spite of a surge in publications dedicated to Treg cells, surprisingly little is known about their induction, biology and mechanisms of action. In this Opinion, we discuss the facts and the controversies regarding their role in transplantation tolerance. We suggest that peripheral generation of Treg cells, crucial for the generation of dominant transplantation tolerance, might be a consequence of sustained suboptimal antigenic stimulation, and that transforming growth factor-beta (TGF-beta) might contribute to this process by increasing the threshold for T-cell activation.

引用

收藏

页码：130 / 135

页数：6

相关论文

共 59 条

[21] Dominant transplantation tolerance - Opinion [J].

Graca, L ;

Le Moine, A ;

Cobbold, SP ;

Waldmann, H .

CURRENT OPINION IN IMMUNOLOGY, 2003, 15 (05) :499-506

[22] Both CD4+CD25+ and CD4+CD25- regulatory cells mediate dominant transplantation tolerance [J].

Graca, L ;

Thompson, S ;

Lin, CY ;

Adams, E ;

Cobbold, SP ;

Waldmann, H .

JOURNAL OF IMMUNOLOGY, 2002, 168 (11) :5558-5565

[23] Cutting edge: Anti-CD154 therapeutic antibodies induce infectious transplantation tolerance [J].

Graca, L ;

Honey, K ;

Adams, E ;

Cobbold, SP ;

Waldmann, H .

JOURNAL OF IMMUNOLOGY, 2000, 165 (09) :4783-4786

[24] CD4+CD25+ T regulatory cells control anti-islet CD8+ T cells through TGF-β-TGF-β receptor interactions in type 1 diabetes [J].

Green, EA ;

Gorelik, L ;

McGregor, CM ;

Tran, EH ;

Flavell, RA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (19) :10878-10883

[25] Dendritic cell modulation by 1α,25 dihydroxyvitamin D3 and its analogs:: A vitamin D receptor-dependent pathway that promotes a persistent state of immaturity in vitro and in vivo [J].

Griffin, MD ;

Lutz, W ;

Phan, VA ;

Bachman, LA ;

McKean, DJ ;

Kumar, R .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (12) :6800-6805

[26]

Honey K, 1999, J IMMUNOL, V163, P4805

[27] Control of regulatory T cell development by the transcription factor Foxp3 [J].

Hori, S ;

Nomura, T ;

Sakaguchi, S .

SCIENCE, 2003, 299 (5609) :1057-1061

[28] Recognition of the peripheral self by naturally arising CD25+ CD4+ T cell receptors [J].

Hsieh, CS ;

Liang, YQ ;

Tyznik, AJ ;

Self, SG ;

Liggitt, D ;

Rudensky, AY .

IMMUNITY, 2004, 21 (02) :267-277

[29] HY peptides modulate transplantation responses to skin allografts [J].

James, E ;

Scott, D ;

Chai, JG ;

Millrain, M ;

Chandler, P ;

Simpson, E .

INTERNATIONAL IMMUNOLOGY, 2002, 14 (11) :1333-1342

[30] Essential role of the E3 ubiquitin ligase Cbl-b in T cell anergy induction [J].

Jeon, MS ;

Atfield, A ;

Venuprasad, K ;

Krawczyk, C ;

Sarao, R ;

Elly, C ;

Yang, C ;

Arya, S ;

Bachmaier, K ;

Su, L ;

Bouchard, D ;

Jones, R ;

Gronski, M ;

Ohashi, P ;

Wada, T ;

Bloom, D ;

Fathman, CG ;

Liu, YC ;

Penninger, JM .

IMMUNITY, 2004, 21 (02) :167-177

← 1 2 3 4 5 6 →