Fabrication of fritless chromatographic microchips packed with conventional reversed-phase silica particles

被引：56

作者：

Gaspar, Attila ^{[1
]}

Piyasena, Menake E. ^{[1
]}

Gomez, Frank A. ^{[1
]}

机构：

[1] Calif State Univ Los Angeles, Dept Chem & Biochem, Los Angeles, CA 90032 USA

来源：

ANALYTICAL CHEMISTRY | 2007年 / 79卷 / 20期

关键词：

D O I：

10.1021/ac071106g

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

This paper describes the development and study of a disposable and inexpensive microfluidic chip, fabricated from poly(dimethylsiloxane) (PDMS) incorporating conventional chromatographic reversed-phase silica particles (C18) without the use of frits, permanent physical barriers, tapers, or restrictors. The packing of C18 modified silica particles into the microfluidic channels is made possible by the hydrophobic nature and excellent elasticity of PDMS. Keystone-, clamping-, and anchor-effects provide the stability and the compactness of the packing and attenuated wall-effects were observed.

引用

页码：7906 / 7909

页数：4

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