Role of Endonucleases XPF and XPG in Nucleotide Excision Repair of Platinated DNA and Cisplatin/Oxaliplatin Cytotoxicity

被引：54

作者：

Graf, Nora ^{[1
]}

Ang, Wee Han ^{[1
]}

Zhu, Guangyu ^{[1
]}

Myint, MyatNoeZin ^{[1
]}

Lippard, Stephen J. ^{[1
]}

机构：

[1] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

CHEMBIOCHEM | 2011年 / 12卷 / 07期

关键词：

cisplatin; DNA damage; DNA repair; XPF; XPG; CISPLATIN-DNA; MOLECULAR-MECHANISMS; POLYMERASE-ETA; RNA; OXALIPLATIN; SENSITIVITY; TRANSCRIPTION; ADDUCTS; DAMAGE; ERCC1;

D O I：

10.1002/cbic.201000724

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Resistance of tumor cells to platinum anticancer agents poses a major problem in cancer chemotherapy. One of the mechanisms associated with platinum-based drug resistance is the enhanced capacity of the cell to carry out nucleotide excision repair (NER) on platinum-damaged DNA. Endonucleases XPF and XPG are critical components of NER, responsible for excising the damaged DNA strand to remove the DNA lesion. Here, we investigated possible consequences of down-regulation of XPF and XPG gene expression in osteosarcoma cancer cells (U2OS) and the impact on cellular transcription and DNA repair. We further evaluated the sensitivity of such cells toward the platinum anticancer drugs cisplatin and oxaliplatin.

引用

收藏

页码：1115 / 1123

页数：9

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