RT-PCR diagnosis of recurrent rearrangements in pediatric acute lymphoblastic leukemia in Argentina

被引：13

作者：

Alonso, Cristina N. ^{[1
]}

Gallego, Marta S. ^{[2
]}

Rossi, Jorge G. ^{[3
]}

Medina, Adriana ^{[1
]}

Rubio, Patricia L. ^{[1
]}

Bernasconi, Andrea R. ^{[3
]}

Zubizarreta, Pedro A. ^{[1
]}

Felice, Maria S. ^{[1
]}

机构：

[1] Hosp Nacl Pediat Prof Dr Juan P Garrahan, Dept Hematol & Oncol, RA-1245 Buenos Aires, DF, Argentina

[2] Hosp Nacl Pediat Prof Dr Juan P Garrahan, Dept Genet, RA-1245 Buenos Aires, DF, Argentina

[3] Hosp Nacl Pediat Prof Dr Juan P Garrahan, Dept Immunol, RA-1245 Buenos Aires, DF, Argentina

来源：

LEUKEMIA RESEARCH | 2012年 / 36卷 / 06期

关键词：

Pediatric; ALL; RT-PCR; Recurrent translocations; Prognosis; Epidemiology; MULTICENTER RANDOMIZED-TRIAL; POLYMERASE CHAIN-REACTION; MINIMAL-RESIDUAL-DISEASE; TEL/AML1 FUSION GENE; SINGLE INSTITUTION; CHILDREN; CHILDHOOD; IDENTIFICATION; FREQUENCY; PROTOCOL;

D O I：

10.1016/j.leukres.2011.12.003

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

The present study was performed to establish the prevalence of the recurrent fusion transcripts in Argentinean pediatric patients with acute lymphoblastic leukemia (ALL). A total of 380 newly diagnosed children (including 50 infants and 44 T-ALL) were screened by RT-PCR; the incidence of recurrent rear-rangements was: ETV6-RUNX1, 12.9%; TCF3-PBX1, 5.0%; BCR-ABL1, 1.6%; and MLL rearrangements, 10.5%. STIL-TAL1 was detected in 22.7% of T-ALL cases. In B-ALL cases, the pEFS was significantly influenced by the presence of genetic alterations. RT-PCR studies improved patients' stratification and also the overall outcome of children treated in a pediatric hospital from a developing country. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：704 / 708

页数：5

共 35 条

[1]

Cytogenetics of Hispanic and white children with acute lymphoblastic leukemia in California [J].

Aldrich, MC ;

Zhang, LP ;

Wiemels, JL ;

Ma, XM ;

Loh, ML ;

Metayer, C ;

Selvin, S ;

Feusner, J ;

Smith, MT ;

Buffler, PA .

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2006, 15 (03) :578-581

[2]

Alonso C, 2007, PEDIATR BLOOD CANCER, V49, P577

[3]

Alonso C, 2009, PEDIATR BLOOD CANCER, V53, P720

[4]

A novel AF9 breakpoint in MLL-AF9-positive acute monoblastic leukemia [J].

Alonso, Cristina N. ;

Longo, Patricia L. Rubio ;

Gallego, Marta S. ;

Medina, Adriana ;

Felice, Maria S. .

PEDIATRIC BLOOD & CANCER, 2008, 50 (04) :869-871

[5]

BTBD18: A novel MLL partner gene in an infant with acute lymphoblastic leukemia and inv(11)(q13;q23) [J].

Alonso, Cristina N. ;

Meyer, Claus ;

Gallego, Marta S. ;

Rossi, Jorge G. ;

Mansini, Adrian P. ;

Rubio, Patricia L. ;

Medina, Adriana ;

Marschalek, Rolf ;

Felice, Maria S. .

LEUKEMIA RESEARCH, 2010, 34 (11) :E294-E296

[6]

Artigas CG, 2006, REV MED CHILE, V134, P1367

[7]

BENE MC, 1995, LEUKEMIA, V9, P1783

[8]

Incidence and clinical relevance of TEL/AML1 fusion genes in children with acute lymphoblastic leukemia enrolled in the German and Italian multicenter therapy trials [J].

Borkhardt, A ;

Cazzaniga, G ;

Viehmann, S ;

Valsecchi, MG ;

Ludwig, WD ;

Burci, L ;

Mangioni, S ;

Schrappe, M ;

Riehm, H ;

Lampert, F ;

Basso, G ;

Masera, G ;

Harbott, J ;

Biondi, A .

BLOOD, 1997, 90 (02) :571-577

[9]

Cabrera Contreras ME, 2001, REV MED CHILE, V129, P634

[10]

Pulses of vincristine and dexamethasone in addition to intensive chemotherapy for children with intermediate-risk acute lymphoblastic leukaemia: a multicentre randomised trial [J].

Conter, Valentino ;

Valsecchi, Maria Grazia ;

Silvestri, Daniela ;

Campbell, Myriam ;

Dibar, Eduardo ;

Magyarosy, Edina ;

Gadner, Helmut ;

Stary, Jan ;

Benoit, Yves ;

Zimmermann, Martin ;

Reiter, Alfred ;

Riehm, Hansjoerg ;

Masera, Giuseppe ;

Schrappe, Martin .

LANCET, 2007, 369 (9556) :123-131

← 1 2 3 4 →