Reduction in Serum High Mobility Group Box-1 Level by Polymyxin B-Immobilized Fiber Column in Patients with Idiopathic Pulmonary Fibrosis with Acute Exacerbation

被引：61

作者：

Abe, Shinji ^{[1
]}

Hayashi, Hiroki ^{[1
]}

Seo, Yoshitsugu ^{[1
]}

Matsuda, Kuniko ^{[1
]}

Kamio, Koichiro ^{[1
]}

Saito, Yoshinobu ^{[1
]}

Usuki, Jiro ^{[1
]}

Azuma, Arata ^{[1
]}

Kudo, Shoji ^{[1
]}

Gemma, Akihiko ^{[1
]}

机构：

[1] Nippon Med Sch, Dept Pulm Med Infect & Oncol, Bunkyo Ku, Tokyo 1138603, Japan

来源：

BLOOD PURIFICATION | 2011年 / 32卷 / 04期

关键词：

High mobility group box-1; Polymyxin B-immobilized fiber column; Idiopathic pulmonary fibrosis; Acute exacerbation; MECHANICAL VENTILATION; DIRECT HEMOPERFUSION; PROGNOSIS; PROTEIN;

D O I：

10.1159/000330325

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Background/Aim: Recent reports suggest that polymyxin B (PMX)-immobilized fiber may have beneficial effects in idiopathic pulmonary fibrosis (IPF) with acute exacerbation (AE). High mobility group box-1 (HMGB-1) is an important pro-inflammatory mediator that contributes to acute lung inflammation. This study was aimed to investigate whether PMX treatment affects serum HMGB-1 levels and oxygenation in IPF patients with AE. Materials and Methods: Twenty IPF patients with AE were treated by PMX. PMX treatment was carried out once daily for 2 successive days. Serum HMGB-1 levels were measured before and after PMX treatment. We also monitored arterial oxygen tension (PaO2)/inspiratory oxygen fraction (FiO(2)) (P/F) ratio. PMX fiber columns were analyzed to examine whether HMGB-1 was absorbed by PMX. Results: PMX treatment significantly improved both the serum HMGB-1 level and P/F ratio. HMGB-1 was detected in washing medium from the PMX column. Conclusion: PMX treatment may reduce serum HMGB-1 and improve oxygenation in patients with IPF with AE. Copyright (C) 2011 S. Karger AG, Basel

引用

页码：310 / 316

页数：7

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